Non-coding RNAs and potential therapeutic targeting in cancer

S Toden, TJ Zumwalt, A Goel - … et Biophysica Acta (BBA)-Reviews on …, 2021 - Elsevier
Recent advances have begun to clarify the physiological and pathological roles of non-
coding RNAs (ncRNAs) in various diseases, including cancer. Among these, microRNAs …

A nuclear long non-coding RNA LINC00618 accelerates ferroptosis in a manner dependent upon apoptosis

Z Wang, X Chen, N Liu, Y Shi, Y Liu, L Ouyang, S Tam… - Molecular Therapy, 2021 - cell.com
Ferroptosis is primarily caused by intracellular iron catalytic activity and lipid peroxidation.
The potential interplay between ferroptosis and apoptosis remains poorly understood. Here …

Functional long non-coding RNAs in hepatocellular carcinoma

C Xie, SY Li, JH Fang, Y Zhu, JE Yang - Cancer Letters, 2021 - Elsevier
Hepatocellular carcinoma (HCC) is a prevalent human malignancy with high morbidity
worldwide. Hepatocarcinogenesis is a complex multistep process, and its underlying …

The involvement of long non-coding RNAs in bone

C Aurilia, S Donati, G Palmini, F Miglietta… - International journal of …, 2021 - mdpi.com
A harmonious balance between osteoblast and osteoclast activity guarantees optimal bone
formation and resorption, pathological conditions affecting the bone may arise. In recent …

[HTML][HTML] Long non-coding RNAs: potential biomarkers and targets for hepatocellular carcinoma therapy and diagnosis

D Yuan, Y Chen, X Li, J Li, Y Zhao, J Shen… - … journal of biological …, 2021 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death
worldwide. Increasing studies showed that long non-coding RNAs (lncRNAs), a novel class …

Pan-cancer characterization of long non-coding RNA and DNA methylation mediated transcriptional dysregulation

Z Yang, F Xu, H Wang, AE Teschendorff, F Xie, Y He - EBioMedicine, 2021 - thelancet.com
Background Disruption of DNA methylation (DNAm) is one of the key signatures of cancer,
however, detailed mechanisms that alter the DNA methylome in cancer remain to be …

The impact of long non-coding RNAs in the pathogenesis of hepatocellular carcinoma

S Ghafouri-Fard, M Gholipour, BM Hussen… - Frontiers in …, 2021 - frontiersin.org
Hepatocellular carcinoma (HCC) is among the utmost deadly human malignancies. This
type of cancer has been associated with several environmental, viral, and lifestyle risk …

LncRNA DANCR represses Doxorubicin-induced apoptosis through stabilizing MALAT1 expression in colorectal cancer cells

M Xiong, M Wu, D Peng, W Huang, Z Chen, H Ke… - Cell death & …, 2021 - nature.com
Long non-coding RNA (lncRNA) DANCR has been reported to participate in key processes
such as stem cell differentiation and tumorigenesis. In a high throughput screening for …

Comprehensive analysis of partial epithelial mesenchymal transition‐related genes in hepatocellular carcinoma

Y Lei, W Yan, Z Lin, J Liu, D Tian… - Journal of Cellular and …, 2021 - Wiley Online Library
Increasing evidence has revealed that cancer cells undergoing an intermediate state, partial
epithelial mesenchymal transition (p‐EMT), tend to metastasize rather than complete EMT …

[HTML][HTML] Non-coding natural antisense transcripts: Analysis and application

JC Krappinger, L Bonstingl, K Pansy, K Sallinger… - Journal of …, 2021 - Elsevier
Non-coding natural antisense transcripts (ncNATs) are regulatory RNA sequences that are
transcribed in the opposite direction to protein-coding or non-coding transcripts. These …