Persistent inflammatory and non-inflammatory mechanisms in refractory rheumatoid arthritis

MH Buch, S Eyre, D McGonagle - Nature Reviews Rheumatology, 2021 - nature.com
Despite nearly three decades of advances in the management of rheumatoid arthritis (RA), a
substantial minority of patients are exposed to multiple DMARDs without necessarily …

Critical role of synovial tissue–resident macrophage and fibroblast subsets in the persistence of joint inflammation

S Kemble, AP Croft - Frontiers in immunology, 2021 - frontiersin.org
Rheumatoid arthritis (RA) is a chronic prototypic immune-mediated inflammatory disease
which is characterized by persistent synovial inflammation, leading to progressive joint …

Serum miRNA signature in rheumatoid arthritis and “at-risk individuals”

CC Cunningham, S Wade, A Floudas, C Orr… - Frontiers in …, 2021 - frontiersin.org
Background MicroRNAs (miRNAs) are small non-coding RNAs which have been implicated
as potential biomarkers or therapeutic targets in autoimmune diseases. This study examines …

Role of microRNA shuttled in small extracellular vesicles derived from mesenchymal stem/stromal cells for osteoarticular disease treatment

E Lara-Barba, MJ Araya, CN Hill… - Frontiers in …, 2021 - frontiersin.org
Osteoarticular diseases (OD), such as rheumatoid arthritis (RA) and osteoarthritis (OA) are
chronic autoimmune/inflammatory and age-related diseases that affect the joints and other …

A review of liquid biopsy as a tool to assess epigenetic, cfDNA and miRNA variability as methotrexate response predictors in patients with rheumatoid arthritis

DN Daraghmeh, C King, MD Wiese - Pharmacological Research, 2021 - Elsevier
Rheumatoid arthritis (RA) is a common autoimmune inflammatory disease affecting 0.5–1%
of adults worldwide. Achieving long term remission or low disease activity is possible …

Circular RNAs as potential theranostics in the cardiac fibrosis

F Yousefi, BM Soltani - Heart failure reviews, 2021 - Springer
Circular RNAs (circRNAs) are a type of single-stranded RNA molecules that normally do not
encode proteins. circRNAs are involved in many physiological processes as well as the …

[PDF][PDF] Somatic mutations cause VEXAS syndrome

S Onuora - Nat Rev Rheumatol, 2021 - iranianra.ir
For patients with rheumatoid arthritis (RA) who achieved sustained (24-week) remission with
the combination of etanercept plus methotrexate (MTX) in the SEAM-RA study (n= 253), the …

miRNAs as potential biomarkers of treatment outcome in rheumatoid arthritis and ankylosing spondylitis

J Wielinska, K Bogunia-Kubik - Pharmacogenomics, 2021 - Taylor & Francis
Common autoimmune, inflammatory rheumatic diseases including rheumatoid arthritis and
ankylosing spondylitis can lead to structural and functional disability, an increase in mortality …

Suppression of inflammatory arthritis by the parasitic worm product ES-62 is associated with epigenetic changes in synovial fibroblasts

M Corbet, MA Pineda, K Yang, A Tarafdar… - PLoS …, 2021 - journals.plos.org
ES-62 is the major secreted protein of the parasitic filarial nematode, Acanthocheilonema
viteae. The molecule exists as a large tetramer (MW,~ 240kD), which possesses …

Pathogenic Role of microRNA in Rheumatoid Arthritis

JJ Yang, JPL Ng, K Zhang, L Liu… - Rheumatoid …, 2021 - books.google.com
Rheumatoid arthritis (RA) being a chronic inflammatory disease can be affected by both
genetic and environmental factors. Abnormal functioning of immune response is the main …