Aberrant DNA methylation plays a pivotal role in tumor development and progression. DNA
hypomethylating agents (HMA) constitute a class of drugs which are able to reverse DNA …

One of the most critical epigenetic signatures present in the genome of higher eukaryotes is
the methylation of DNA at the C-5 position of the cytosine ring. Based on the sites of DNA …

The prevalence of type 2 diabetes mellitus (T2DM) continues to rise globally. Yet the
aetiology and pathophysiology of this noncommunicable, polygenic disease, is poorly …

Enzyme-mediated chemical modifications of nucleic acids are indispensable regulators of
gene expression. Our understanding of the biochemistry and biological significance of these …

DNA methylation is found throughout all domains of life, yet the extent and function of DNA
methylation differ among eukaryotes. Strains of the plant pathogenic fungus Zymoseptoria …

Animal and humans exposed to stress early in life are more likely to suffer from long-term
behavioral, mental health, metabolic, immune, and cardiovascular health consequences …

Background The combination of milbemycin oxime (MO) and lotilaner (Credelio® Plus) is a
novel systemic endectocide that provides month-long effectiveness in dogs after a single …

Chronic exposure to stress throughout lifespan alters brain structure and function, inducing a
maladaptive response to environmental stimuli, that can contribute to the development of a …

Many species are threatened by climate change and must rapidly respond to survive
changing environments. Epigenetic modifications, such as DNA methylation, can facilitate …

Alcohol is one of the most consumed drugs of abuse, with about 140 million Americans over
the age of 12 having consumed alcohol, a prevalence that has significantly increased in the …