Analgesic potential of terpenes derived from Cannabis sativa

E Liktor-Busa, A Keresztes, J LaVigne… - Pharmacological …, 2021 - ASPET
Pain prevalence among adults in the United States has increased 25% over the past two
decades, resulting in high health-care costs and impacts to patient quality of life. In the last …

[HTML][HTML] Cannabis: a toxin-producing plant with potential therapeutic uses

Z Breijyeh, B Jubeh, SA Bufo, R Karaman, L Scrano - Toxins, 2021 - mdpi.com
For thousands of years, Cannabis sativa has been utilized as a medicine and for
recreational and spiritual purposes. Phytocannabinoids are a family of compounds that are …

[HTML][HTML] Oxidative stress and lipid mediators modulate immune cell functions in autoimmune diseases

P Wójcik, A Gęgotek, N Žarković… - International journal of …, 2021 - mdpi.com
Autoimmune diseases, including psoriasis, systemic lupus erythematosus (SLE), and
rheumatic arthritis (RA), are caused by a combination of environmental and genetic factors …

[HTML][HTML] Major phytocannabinoids and their related compounds: should we only search for drugs that act on cannabinoid receptors?

LE Filipiuc, DC Ababei, T Alexa-Stratulat, CV Pricope… - Pharmaceutics, 2021 - mdpi.com
The most important discoveries in pharmacology, such as certain classes of analgesics or
chemotherapeutics, started from natural extracts which have been found to have effects in …

Cannabis and cannabis edibles: a review

H Peng, F Shahidi - Journal of Agricultural and Food Chemistry, 2021 - ACS Publications
Cannabis is an excellent natural source of fiber and various bioactive cannabinoids. So far,
at least 120 cannabinoids have been identified, and more novel cannabinoids are gradually …

[HTML][HTML] Bioactive terpenes and their derivatives as potential SARS-CoV-2 proteases inhibitors from molecular modeling studies

LRL Diniz, Y Perez-Castillo, HA Elshabrawy… - Biomolecules, 2021 - mdpi.com
The coronavirus disease 2019 (COVID-19) pandemic is caused by a novel coronavirus; the
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Millions of cases and …

[HTML][HTML] Pharmacological properties, therapeutic potential and molecular mechanisms of JWH133, a CB2 receptor-selective agonist

HM Hashiesh, C Sharma, SN Goyal, NK Jha… - Frontiers in …, 2021 - frontiersin.org
The endocannabinoid system has attracted attention as a pharmacological target for several
pathological conditions. Cannabinoid (CB2)-selective agonists have been the focus of …

[HTML][HTML] Pharmacological and toxicological effects of phytocannabinoids and recreational synthetic cannabinoids: Increasing risk of public health

VN Bukke, M Archana, R Villani, G Serviddio… - Pharmaceuticals, 2021 - mdpi.com
Synthetic Cannabinoids (CBs) are a novel class of psychoactive substances that have
rapidly evolved around the world with the addition of diverse structural modifications to …

pysisyphus: Exploring potential energy surfaces in ground and excited states

J Steinmetzer, S Kupfer, S Gräfe - International Journal of …, 2021 - Wiley Online Library
Predicting the energetics of chemical transformations requires localizing stationary points on
a potential energy surface. While educts and products of a chemical reaction may be known …

[HTML][HTML] Neuroprotective effects of cannabidiol but not Δ9-tetrahydrocannabinol in rat hippocampal slices exposed to oxygen-glucose deprivation: studies with …

E Landucci, C Mazzantini, D Lana, PL Davolio… - International Journal of …, 2021 - mdpi.com
(1) Background: Over the past 10 years, a number of scientific studies have demonstrated
the therapeutic potential of cannabinoid compounds present in the Cannabis Sativa and …