Biofilm-innate immune interface: contribution to chronic wound formation

Z Versey, WS da Cruz Nizer, E Russell, S Zigic… - Frontiers in …, 2021 - frontiersin.org
Delayed wound healing can cause significant issues for immobile and ageing individuals as
well as those living with co-morbid conditions such as diabetes, cardiovascular disease, and …

Green tea derivative driven smart hydrogels with desired functions for chronic diabetic wound treatment

X Zhao, D Pei, Y Yang, K Xu, J Yu… - Advanced Functional …, 2021 - Wiley Online Library
Current treatments for chronic diabetic wounds remain unsatisfactory due to the lack of ideal
wound dressings that can integrate matching mechanical strength, fast self‐healability, facile …

Dermal drivers of injury-induced inflammation: contribution of adipocytes and fibroblasts

PO Cooper, MER Haas, SKR Noonepalle… - International journal of …, 2021 - mdpi.com
Irregular inflammatory responses are a major contributor to tissue dysfunction and inefficient
repair. Skin has proven to be a powerful model to study mechanisms that regulate …

Murine model of colonization with fungal pathogen Candida auris to explore skin tropism, host risk factors and therapeutic strategies

X Huang, C Hurabielle, RA Drummond, N Bouladoux… - Cell host & …, 2021 - cell.com
Candida auris is an emerging multi-drug-resistant human fungal pathogen. C. auris skin
colonization results in environmental shedding, which underlies hospital transmissions, and …

Human exosomes accelerate cutaneous wound healing by promoting collagen synthesis in a diabetic mouse model

B Zhao, X Zhang, Y Zhang, Y Lu, W Zhang… - Stem cells and …, 2021 - liebertpub.com
Chronic wounds including diabetic foot ulcers are clinical emergencies that need careful
management. Exosomes from human adipose-derived mesenchymal stem cells (hADSCs …

Microbiota instruct IL-17A-producing innate lymphoid cells to promote skin inflammation in cutaneous leishmaniasis

TP Singh, AM Carvalho, LA Sacramento… - PLoS …, 2021 - journals.plos.org
Innate lymphoid cells (ILCs) comprise a heterogeneous population of immune cells that
maintain barrier function and can initiate a protective or pathological immune response upon …

Self‐amplification immunomodulatory strategy for tissue regeneration in diabetes based on cytokine‐ZIFs system

G Guo, T Gong, H Shen, Q Wang… - Advanced Functional …, 2021 - Wiley Online Library
Dysfunctional macrophages and excessive inflammatory responses lead to severe tissue
regeneration disorders in diabetes. Herein, a function‐oriented self‐amplification …

Effect of collagen and EPS components on the viscoelasticity of Pseudomonas aeruginosa biofilms

MU Rahman, DF Fleming, I Sinha, KP Rumbaugh… - Soft Matter, 2021 - pubs.rsc.org
Pseudomonas aeruginosa is an opportunistic pathogen that causes thousands of deaths
every year in part due to its ability to form biofilms composed of bacteria embedded in a …

The ambivalent role of skin microbiota and adrenaline in wound healing and the interplay between them

A Luqman, F Götz - International Journal of Molecular Sciences, 2021 - mdpi.com
After skin injury, wound healing sets into motion a dynamic process to repair and replace
devitalized tissues. The healing process can be divided into four overlapping phases …

The skin microbiota in equine pastern dermatitis: a case‐control study of horses in Switzerland

S Kaiser‐Thom, M Hilty, S Axiak… - Veterinary …, 2021 - Wiley Online Library
Background Equine pastern dermatitis (EPD), a multifactorial syndrome, manifests as skin
lesions of variable severity in the pastern area. Despite the widespread use of antibacterial …