Patients with chronic lymphocytic leukemia can be divided into three categories: those who
are minimally affected by the problem, often never requiring therapy; those that initially …

Chronic lymphocytic leukaemia (CLL) is the most common leukaemia in the Western world
with an incidence of 4.2/100 000/year. The incidence increases to more than 30/100 …

Simple Summary Chronic lymphocytic leukemia (CLL) is characterized by a highly variable
clinical course. Thus, predicting the outcome of patients with this disease is a topic of special …

BIRC3 is monoallelically deleted in up to 80% of chronic lymphocytic leukemia (CLL) cases
harboring del (11q). In addition, truncating mutations in the remaining allele of this gene can …

Abstract Purpose of Review Richter syndrome (RS) is an uncommon but aggressive
evolution of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). RS is an …

The introduction of agents inhibiting the B-cell receptor-associated kinases such as ibrutinib
has dramatically changed treatments algorithms of chronic lymphocytic leukemia (CLL) as …

This atlas presents not only the differential diagnosis but also the detailed morphologic,
immunophenotypic, and especially genetic characteristics of the majority of hematolymphoid …

Genome engineering makes the precise manipulation of DNA sequences possible in a cell.
Therefore, it is essential for understanding gene function. Meganucleases were the start of …

Purpose NOTCH1 mut represents a new prognostic marker in chronic lymphocytic
leukaemia (CLL). The low sensitivity of the current methods may increase the risk of false …

Simple Summary Chronic lymphocytic leukemia harbors a high degree of genetic variability
and interpatient heterogeneity. Some of the genetic alterations have an impact on the …