Mitochondria are multifunctional subcellular organelles essential for cellular energy
homeostasis and apoptotic cell death. It is, therefore, crucial to maintain mitochondrial …

Protein ubiquitination has become one of the most extensively studied post-translational
modifications. Originally discovered as a critical element in highly regulated proteolysis …

The contribution of the Ubiquitin-Proteasome System (UPS) to mitophagy has been largely
attributed to the E3 ubiquitin ligase Parkin. Here we show that in response to the oxidative …

The serine/threonine kinase ULK1 mediates autophagy initiation in response to various
cellular stresses, and genetic deletion of ULK1 leads to accumulation of damaged …

Mitochondria in the cell are the center for energy production, essential biomolecule
synthesis, and cell fate determination. Moreover, the mitochondrial functional versatility …

Cell state changes are associated with proteome remodeling to serve newly emergent cell
functions. Here, we show that NGN2-driven conversion of human embryonic stem cells to …

The activity of the mitochondrial permeability transition pore, mPTP, a highly regulated multi-
component mega-channel, is enhanced in aging and in aging-driven degenerative …

The familial form of Parkinson's disease (PD) is linked to mutations in specific genes. The
mutations in parkin are one of the most common causes of early-onset PD. Mitochondrial …

Clearance of mitochondria following damage is critical for neuronal homeostasis. Here, we
investigate the role of Miro proteins in mitochondrial turnover by the PINK1/Parkin …

How activation of PINK1 and Parkin leads to elimination of damaged mitochondria by
mitophagy is largely based on cell lines with few studies in neurons. Here, we have …