Mitophagy: molecular mechanisms, new concepts on parkin activation and the emerging role of AMPK/ULK1 axis
R Iorio, G Celenza, S Petricca - Cells, 2021 - mdpi.com
Mitochondria are multifunctional subcellular organelles essential for cellular energy
homeostasis and apoptotic cell death. It is, therefore, crucial to maintain mitochondrial …
homeostasis and apoptotic cell death. It is, therefore, crucial to maintain mitochondrial …
Beyond K48 and K63: non-canonical protein ubiquitination
M Tracz, W Bialek - Cellular & molecular biology letters, 2021 - Springer
Protein ubiquitination has become one of the most extensively studied post-translational
modifications. Originally discovered as a critical element in highly regulated proteolysis …
modifications. Originally discovered as a critical element in highly regulated proteolysis …
[HTML][HTML] Ubiquitination and receptor-mediated mitophagy converge to eliminate oxidation-damaged mitochondria during hypoxia
P Sulkshane, J Ram, A Thakur, N Reis, O Kleifeld… - Redox biology, 2021 - Elsevier
The contribution of the Ubiquitin-Proteasome System (UPS) to mitophagy has been largely
attributed to the E3 ubiquitin ligase Parkin. Here we show that in response to the oxidative …
attributed to the E3 ubiquitin ligase Parkin. Here we show that in response to the oxidative …
AMPK/ULK1-mediated phosphorylation of Parkin ACT domain mediates an early step in mitophagy
CM Hung, PS Lombardo, N Malik, SN Brun… - Science …, 2021 - science.org
The serine/threonine kinase ULK1 mediates autophagy initiation in response to various
cellular stresses, and genetic deletion of ULK1 leads to accumulation of damaged …
cellular stresses, and genetic deletion of ULK1 leads to accumulation of damaged …
Molecular mechanisms and regulation of mammalian mitophagy
V Choubey, A Zeb, A Kaasik - Cells, 2021 - mdpi.com
Mitochondria in the cell are the center for energy production, essential biomolecule
synthesis, and cell fate determination. Moreover, the mitochondrial functional versatility …
synthesis, and cell fate determination. Moreover, the mitochondrial functional versatility …
Temporal proteomics during neurogenesis reveals large-scale proteome and organelle remodeling via selective autophagy
Cell state changes are associated with proteome remodeling to serve newly emergent cell
functions. Here, we show that NGN2-driven conversion of human embryonic stem cells to …
functions. Here, we show that NGN2-driven conversion of human embryonic stem cells to …
The mitochondrial permeability transition: nexus of aging, disease and longevity
H Rottenberg, JB Hoek - Cells, 2021 - mdpi.com
The activity of the mitochondrial permeability transition pore, mPTP, a highly regulated multi-
component mega-channel, is enhanced in aging and in aging-driven degenerative …
component mega-channel, is enhanced in aging and in aging-driven degenerative …
Multitasking guardian of mitochondrial quality: Parkin function and Parkinson's disease
I Kamienieva, J Duszyński… - Translational …, 2021 - Springer
The familial form of Parkinson's disease (PD) is linked to mutations in specific genes. The
mutations in parkin are one of the most common causes of early-onset PD. Mitochondrial …
mutations in parkin are one of the most common causes of early-onset PD. Mitochondrial …
Loss of neuronal Miro1 disrupts mitophagy and induces hyperactivation of the integrated stress response
G López‐Doménech, JH Howden… - The EMBO …, 2021 - embopress.org
Clearance of mitochondria following damage is critical for neuronal homeostasis. Here, we
investigate the role of Miro proteins in mitochondrial turnover by the PINK1/Parkin …
investigate the role of Miro proteins in mitochondrial turnover by the PINK1/Parkin …
Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1
How activation of PINK1 and Parkin leads to elimination of damaged mitochondria by
mitophagy is largely based on cell lines with few studies in neurons. Here, we have …
mitophagy is largely based on cell lines with few studies in neurons. Here, we have …