Insulin resistance, defined as a defect in insulin-mediated control of glucose metabolism in
tissues—prominently in muscle, fat and liver—is one of the earliest manifestations of a …

Lipodystrophies have been recognized since at least the nineteenth century and, despite
their rarity, tended to attract considerable medical attention because of the severity and …

Summary Fgf21 (fibroblast growth factor 21) is a regulatory hepatokine that, in
pharmacologic form, powerfully promotes weight loss and glucose homeostasis. Although" …

Insulin's activation of PI3K/Akt signaling, stimulates glucose uptake by enhancing delivery of
GLUT4 to the cell surface. Here we examined the origins of intercellular heterogeneity in …

Selective hepatic insulin resistance is a feature of obesity and type 2 diabetes. Whether
similar mechanisms operate in white adipose tissue (WAT) of those with obesity and to what …

Metabolic dysfunction and insulin resistance are emerging as hallmarks of cancer and
cachexia, and impair cancer prognosis. Yet, the molecular mechanisms underlying impaired …

The proper functional interaction between different tissues represents a key component in
systemic metabolic control. Indeed, disruption of endocrine inter-tissue communication is a …

Adipogenesis is a finely orchestrated program involving a transcriptional cascade
coordinated by CEBP and PPAR family members and by hormonally induced signaling …

Introduction Adipose tissue and adipocytes are primary regulators of insulin sensitivity and
energy homeostasis. Defects in insulin sensitivity of the adipocytes predispose the body to …

In the present study, we associated a high‐fat diet (HF group: 45% kcal from lipids) or very
high‐fat (VHF group: 60% kcal from lipids) diet with a fructose drink (10% fructose) for …