Human structural congenital malformations are the leading cause of infant mortality in the
United States. Estimates from the United States Center for Disease Control and Prevention …

Neural tube defects (NTDs) are a classic example of preventable birth defects for which
there is a proven‐effective intervention, folic acid (FA); however, further methods of …

Mucociliary clearance is an essential lung function that facilitates the removal of inhaled
pathogens and foreign matter unidirectionally from the airway tract and is innately achieved …

The four-pass transmembrane proteins Vangl1 and Vangl2 are dedicated core components
of Wnt/planar cell polarity (Wnt/PCP) signaling that critically regulate polarized cell …

The neural tube is the first critically important structure that develops in the embryo. It serves
as the primordium of the central nervous system; therefore, the proper formation of the …

During dentin formation, odontoblast polarization ensures that odontoblasts directionally
secrete dentin matrix protein, leading to tubular dentin formation; however, little is known …

We identify an intronic deletion in VANGL1 that predisposes to renal injury in high risk
populations through a kidney-intrinsic process. Half of all SLE patients develop nephritis, yet …

Background: Anencephaly is a rare but lethal congenital anomaly of the neural tube. Ideally,
the diagnosis is made early in pregnancy and the pregnancy is usually terminated. This is to …

Background Neural tube defect (NTD) is a common birth defect causing much death in the
world. Variants in VANGL1 lead to NTD and caudal regression syndrome. NTD displays a …

Perosomus elumbis (PE) is a lethal, congenital defect marked by aplasia of the lumbar and
sacral spine and spinal cord. Contracture of the hind limbs is also commonly observed in …