From menopause to neurodegeneration—molecular basis and potential therapy
The impacts of menopause on neurodegenerative diseases, especially the changes in
steroid hormones, have been well described in cell models, animal models, and humans …
steroid hormones, have been well described in cell models, animal models, and humans …
Targeting nuclear receptors in neurodegeneration and neuroinflammation
S Willems, D Zaienne, D Merk - Journal of medicinal chemistry, 2021 - ACS Publications
Nuclear receptors, also known as ligand-activated transcription factors, regulate gene
expression upon ligand signals and present as attractive therapeutic targets especially in …
expression upon ligand signals and present as attractive therapeutic targets especially in …
17-β estradiol rescued immature rat brain against glutamate-induced oxidative stress and neurodegeneration via regulating Nrf2/HO-1 and MAP-kinase signaling …
Dysregulated glutamate signaling, leading to neuronal excitotoxicity and death, has been
associated with neurodegenerative pathologies. 17β-estradiol (E2) is a human steroid …
associated with neurodegenerative pathologies. 17β-estradiol (E2) is a human steroid …
Repurposing immunomodulatory Imide Drugs (IMiDs) in neuropsychiatric and neurodegenerative disorders
YJ Jung, D Tweedie, MT Scerba, DS Kim… - Frontiers in …, 2021 - frontiersin.org
Neuroinflammation represents a common trait in the pathology and progression of the major
psychiatric and neurodegenerative disorders. Neuropsychiatric disorders have emerged as …
psychiatric and neurodegenerative disorders. Neuropsychiatric disorders have emerged as …
Recuperative effect of estrogen on rotenone-induced experimental model of Parkinson's disease in rats
Parkinson's disease (PD) is described as the loss of dopaminergic neurons located in the
substantia nigra (SN) region of the brain and a progressive motor failure. Increased …
substantia nigra (SN) region of the brain and a progressive motor failure. Increased …
Sex-related motor deficits in the tau-p301l mouse model
The contribution of mouse models for basic and translational research at different levels is
important to understand neurodegenerative diseases, including tauopathies, by studying the …
important to understand neurodegenerative diseases, including tauopathies, by studying the …
Sex differences in recovery of motor function in a rhesus monkey model of cortical injury
KR Bottenfield, BGE Bowley, MA Pessina… - Biology of sex …, 2021 - Springer
Background Stroke disproportionately affects men and women, with women over 65 years
experiencing increased severity of impairment and higher mortality rates than men. Human …
experiencing increased severity of impairment and higher mortality rates than men. Human …
Microglial MorphOMICs unravel region-and sex-dependent morphological phenotypes from postnatal development to degeneration
Microglia contribute to tissue homeostasis in physiological conditions with environmental
cues influencing their ever-changing morphology. Strategies to identify these changes …
cues influencing their ever-changing morphology. Strategies to identify these changes …
Macrophages in the uterus are functionally specialised and continually replenished from the circulation
Macrophages are innate immune cells that fight infection but also regulate tissue
regeneration and remodelling. In the uterus, although tissue remodelling is essential for …
regeneration and remodelling. In the uterus, although tissue remodelling is essential for …
[PDF][PDF] Sex-Related Motor Deficits in the Tau-P301L Mouse Model. Biomedicines 2021, 9, 1160
The contribution of mouse models for basic and translational research at different levels is
important to understand neurodegenerative diseases, including tauopathies, by studying the …
important to understand neurodegenerative diseases, including tauopathies, by studying the …