The signal pathways and treatment of cytokine storm in COVID-19

L Yang, X Xie, Z Tu, J Fu, D Xu, Y Zhou - Signal transduction and …, 2021 - nature.com
Abstract The Coronavirus Disease 2019 (COVID-19) pandemic has become a global crisis
and is more devastating than any other previous infectious disease. It has affected a …

COVID-19: angiotensin-converting enzyme 2 (ACE2) expression and tissue susceptibility to SARS-CoV-2 infection

S Beyerstedt, EB Casaro, ÉB Rangel - European journal of clinical …, 2021 - Springer
COVID-19 pandemic is caused by the novel coronavirus SARS-CoV-2. Angiotensin-
converting enzyme 2 (ACE2) is not only an enzyme but also a functional receptor on cell …

Pathogenesis of multiple organ injury in COVID-19 and potential therapeutic strategies

M Lopes-Pacheco, PL Silva, FF Cruz… - Frontiers in …, 2021 - frontiersin.org
Severe acute respiratory disease coronavirus 2 (SARS-CoV-2, formerly 2019-nCoV) is a
novel coronavirus that has rapidly disseminated worldwide, causing the coronavirus disease …

Insulin resistance in COVID-19 and diabetes

N Govender, OP Khaliq, J Moodley, T Naicker - Primary Care Diabetes, 2021 - Elsevier
Background The epidemiology of COVID-19 and its association with cardiometabolic
disorders is poorly understood. This is a narrative review that investigates the effects of …

Air pollution by NO2 and PM2.5 explains COVID-19 infection severity by overexpression of angiotensin-converting enzyme 2 in respiratory cells: a review

B Paital, PK Agrawal - Environmental Chemistry Letters, 2021 - Springer
Many major cities that witnessed heavy air pollution by nitrogen dioxide (NO 2) and
particulate matter (PM) have experienced a high rate of infection and severity of the …

The green tea catechin epigallocatechin gallate inhibits SARS-CoV-2 infection

L Henss, A Auste, C Schürmann… - Journal of General …, 2021 - microbiologyresearch.org
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection has caused a
pandemic with tens of millions of cases and more than a million deaths. The infection causes …

SARS-CoV-2 mediated endothelial dysfunction: the potential role of chronic oxidative stress

R Chang, A Mamun, A Dominic, NT Le - Frontiers in physiology, 2021 - frontiersin.org
Endothelial cells have emerged as key players in SARS-CoV-2 infection and COVID-19
inflammatory pathologies. Dysfunctional endothelial cells can promote chronic inflammation …

Alveolar epithelial cell type II as main target of SARS-CoV-2 virus and COVID-19 development via NF-Kb pathway deregulation: A physio-pathological theory

M Carcaterra, C Caruso - Medical hypotheses, 2021 - Elsevier
Abstract The Corona Virus Disease (COVID-19) pandemic caused by Severe Acute
Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) requires a rapid solution and global …

The flexibility of ACE2 in the context of SARS-CoV-2 infection

EP Barros, L Casalino, Z Gaieb, AC Dommer, Y Wang… - Biophysical journal, 2021 - cell.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has swept over the world in
the past months, causing significant loss of life and consequences to human health …

Intestinal inflammation modulates the expression of ACE2 and TMPRSS2 and potentially overlaps with the pathogenesis of SARS-CoV-2–related disease

M Suárez-Fariñas, M Tokuyama, G Wei, R Huang… - Gastroenterology, 2021 - Elsevier
Background and Aims The presence of gastrointestinal symptoms and high levels of viral
RNA in the stool suggest active severe acute respiratory syndrome coronavirus 2 (SARS …