The bioinformatics toolbox for circRNA discovery and analysis
Circular RNAs (circRNAs) are a unique class of RNA molecule identified more than 40 years
ago which are produced by a covalent linkage via back-splicing of linear RNA. Recent …
ago which are produced by a covalent linkage via back-splicing of linear RNA. Recent …
[HTML][HTML] From genotypes to organisms: State-of-the-art and perspectives of a cornerstone in evolutionary dynamics
Understanding how genotypes map onto phenotypes, fitness, and eventually organisms is
arguably the next major missing piece in a fully predictive theory of evolution. We refer to this …
arguably the next major missing piece in a fully predictive theory of evolution. We refer to this …
BioSeq-BLM: a platform for analyzing DNA, RNA and protein sequences based on biological language models
In order to uncover the meanings of 'book of life', 155 different biological language models
(BLMs) for DNA, RNA and protein sequence analysis are discussed in this study, which are …
(BLMs) for DNA, RNA and protein sequence analysis are discussed in this study, which are …
[HTML][HTML] In vivo reconstitution finds multivalent RNA–RNA interactions as drivers of mesh-like condensates
Liquid-like condensates have been thought to be sphere-like. Recently, various
condensates with filamentous morphology have been observed in cells. One such …
condensates with filamentous morphology have been observed in cells. One such …
[HTML][HTML] Structured elements drive extensive circular RNA translation
The human genome encodes tens of thousands circular RNAs (circRNAs) with mostly
unknown functions. Circular RNAs require internal ribosome entry sites (IRES) if they are to …
unknown functions. Circular RNAs require internal ribosome entry sites (IRES) if they are to …
[HTML][HTML] Predicting dynamic cellular protein–RNA interactions by deep learning using in vivo RNA structures
Interactions with RNA-binding proteins (RBPs) are integral to RNA function and cellular
regulation, and dynamically reflect specific cellular conditions. However, presently available …
regulation, and dynamically reflect specific cellular conditions. However, presently available …
A map of the SARS-CoV-2 RNA structurome
RJ Andrews, CA O'Leary, VS Tompkins… - NAR genomics and …, 2021 - academic.oup.com
SARS-CoV-2 has exploded throughout the human population. To facilitate efforts to gain
insights into SARS-CoV-2 biology and to target the virus therapeutically, it is essential to …
insights into SARS-CoV-2 biology and to target the virus therapeutically, it is essential to …
Design and self-assembly of siRNA-functionalized RNA nanoparticles for use in automated nanomedicine
250Individual genes can be targeted with siRNAs. The use of nucleic acid nanoparticles
(NPs) is a convenient method for delivering combinations of specific siRNAs in an organized …
(NPs) is a convenient method for delivering combinations of specific siRNAs in an organized …
Delivery, engineering and optimization of tandem guide systems, methods and compositions for sequence manipulation
F Zhang, C Lin, RAN Fei - US Patent 11,008,588, 2021 - Google Patents
2016-06-20 Assigned to NATIONAL INSTITUTES OF HEALTH (NIH), US DEPT. OF HEALTH
AND HUMAN SERVICES (DHHS), US GOVERNMENT reassignment NATIONAL …
AND HUMAN SERVICES (DHHS), US GOVERNMENT reassignment NATIONAL …
Lateral flow colorimetric biosensor for detection of Vibrio parahaemolyticus based on hybridization chain reaction and aptamer
N Ying, Y Wang, X Song, L Yang, B Qin, Y Wu… - Microchimica Acta, 2021 - Springer
Vibrio parahaemolyticus (V. parahaemolyticus) is the causative agent for acute
hepatopancreatic necrosis disease (AHPND) of shrimp, and it is also a common seafood …
hepatopancreatic necrosis disease (AHPND) of shrimp, and it is also a common seafood …