Cancer stem cells (CSCs) show a self-renewal capacity and differentiation potential that
contribute to tumor progression and therapy resistance. However, the underlying processes …

Simple Summary Cancer stem cells (CSCs) are a tumor cell population maintaining tumor
growth and promoting tumor relapse if not wholly eradicated during treatment. CSCs are …

Peroxynitrite (ONOO–) and glutathione (GSH), two unique reactive species, play an
essential regulating role in the oxidation and antioxidation in the living body and are closely …

Background: Hypoxia is a hallmark of the physical microenvironment of solid tumors. As a
key factor that regulates tumor development and progression, hypoxia can reprogram the …

The transcription factor nuclear factor erythroid 2-like 2 (NEF2L2; NRF2) plays crucial roles
in the defense system against electrophilic or oxidative stress by upregulating an array of …

Methylmercury (MeHg) is a long-lasting organic environmental pollutant that poses a great
threat to human health. Ingestion of seafood containing MeHg is the most important way by …

Simple Summary Although many methods have been applied in clinical treatment for
tumors, they still always show a poor prognosis. Molecule targeted therapy has …

Over the past 20 years cancer stem cells (CSCs) have been proposed as key players in the
tumorigenesis and progression, which are closely related to the initiation, metastasis and …

At present, after extensive studies in the field of cancer, cancer stem cells (CSCs) have been
proposed as a major factor in tumor initiation, progression, metastasis, and recurrence …

The developmental programs that build and sustain animal forms also encode the capacity
to sense and adapt to the microbial world within which they evolved. This is abundantly …