Asthma in the precision medicine era: biologics and probiotics

CJ Chiu, MT Huang - International Journal of Molecular Sciences, 2021 - mdpi.com
Asthma is a major global health issue. Over 300 million people worldwide suffer from this
chronic inflammatory airway disease. Typical clinical symptoms of asthma are characterized …

Biological therapies targeting the type 2 inflammatory pathway in severe asthma

AP Fildan, RM Rajnoveanu… - Experimental and …, 2021 - spandidos-publications.com
Asthma is a variable chronic respiratory disease characterized by airway inflammation and
hyperresponsiveness, bronchoconstriction, and mucus hypersecretion. While most patients …

Environmental allergens house dust mite‑induced asthma is associated with ferroptosis in the lungs

W Tang, M Dong, F Teng, J Cui… - Experimental and …, 2021 - spandidos-publications.com
Previous studies have indicated that allergens such as house dust mites (HDM) in the
environment can induce allergic asthma. Ferroptosis is a newly discovered form of …

T2-High Endotype and Response to Biological Treatments in Patients with Bronchiectasis

M Oriano, A Gramegna, F Amati, A D'Adda, M Gaffuri… - Biomedicines, 2021 - mdpi.com
Although bronchiectasis pathophysiology has been historically understood around the
presence of airway neutrophilic inflammation, recent experiences are consistent with the …

Suppression of autophagy through JAK2/STAT3 contributes to the therapeutic action of rhynchophylline on asthma

H Li, Q Bi, H Cui, C Lv, M Wang - BMC Complementary Medicine and …, 2021 - Springer
Background Asthma is a chronic inflammatory disease characterized by airway remodeling
and inflammation. Rhynchophylline is a kind of indole alkaloid isolated from Uncaria …

[HTML][HTML] Biomarkers for severe asthma: lessons from longitudinal cohort studies

Y Lee, QL Quoc, HS Park - Allergy, Asthma & Immunology …, 2021 - ncbi.nlm.nih.gov
Severe asthma (SA) is a heterogeneous disease characterized by uncontrolled symptoms,
frequent exacerbations, and lung function decline. The discovery of phenotypes and …

Prospects for severe asthma treatment

L Calzetta, MG Matera, A Coppola… - Current Opinion in …, 2021 - Elsevier
Biological drugs are approved to treat patients with severe uncontrolled asthma and are
directed against mediators of type 2 immunity. These agents are effective in reducing the risk …

Long noncoding RNA LINC-PINT retards the abnormal growth of airway smooth muscle cells via regulating the microRNA-26a-5p/PTEN axis in asthma

P Gao, Y Ding, B Yin, H Gu - International Immunopharmacology, 2021 - Elsevier
Background Asthma is a chronic respiratory disease worldwide. This study aimed to explore
the functions of the long noncoding RNA LINC-PINT (LINC-PINT) in asthma and to …

Treatable mechanisms in asthma

M Cazzola, J Ora, F Cavalli, P Rogliani… - Molecular Diagnosis & …, 2021 - Springer
Asthma is a heterogeneous condition, but firm identification of heterogeneity-focused
treatments is still lacking. Dividing patients into subgroups of asthma pheno-/endotypes …

Molecular targets for biological therapies of severe asthma: focus on benralizumab and tezepelumab

SL Cheng - Life, 2021 - mdpi.com
Asthma is a heterogeneous respiratory disease characterized by usually reversible
bronchial obstruction, which is clinically expressed by different phenotypes driven by …