Asthma in the precision medicine era: biologics and probiotics
CJ Chiu, MT Huang - International Journal of Molecular Sciences, 2021 - mdpi.com
Asthma is a major global health issue. Over 300 million people worldwide suffer from this
chronic inflammatory airway disease. Typical clinical symptoms of asthma are characterized …
chronic inflammatory airway disease. Typical clinical symptoms of asthma are characterized …
Biological therapies targeting the type 2 inflammatory pathway in severe asthma
AP Fildan, RM Rajnoveanu… - Experimental and …, 2021 - spandidos-publications.com
Asthma is a variable chronic respiratory disease characterized by airway inflammation and
hyperresponsiveness, bronchoconstriction, and mucus hypersecretion. While most patients …
hyperresponsiveness, bronchoconstriction, and mucus hypersecretion. While most patients …
Environmental allergens house dust mite‑induced asthma is associated with ferroptosis in the lungs
W Tang, M Dong, F Teng, J Cui… - Experimental and …, 2021 - spandidos-publications.com
Previous studies have indicated that allergens such as house dust mites (HDM) in the
environment can induce allergic asthma. Ferroptosis is a newly discovered form of …
environment can induce allergic asthma. Ferroptosis is a newly discovered form of …
T2-High Endotype and Response to Biological Treatments in Patients with Bronchiectasis
Although bronchiectasis pathophysiology has been historically understood around the
presence of airway neutrophilic inflammation, recent experiences are consistent with the …
presence of airway neutrophilic inflammation, recent experiences are consistent with the …
Suppression of autophagy through JAK2/STAT3 contributes to the therapeutic action of rhynchophylline on asthma
H Li, Q Bi, H Cui, C Lv, M Wang - BMC Complementary Medicine and …, 2021 - Springer
Background Asthma is a chronic inflammatory disease characterized by airway remodeling
and inflammation. Rhynchophylline is a kind of indole alkaloid isolated from Uncaria …
and inflammation. Rhynchophylline is a kind of indole alkaloid isolated from Uncaria …
[HTML][HTML] Biomarkers for severe asthma: lessons from longitudinal cohort studies
Severe asthma (SA) is a heterogeneous disease characterized by uncontrolled symptoms,
frequent exacerbations, and lung function decline. The discovery of phenotypes and …
frequent exacerbations, and lung function decline. The discovery of phenotypes and …
Prospects for severe asthma treatment
L Calzetta, MG Matera, A Coppola… - Current Opinion in …, 2021 - Elsevier
Biological drugs are approved to treat patients with severe uncontrolled asthma and are
directed against mediators of type 2 immunity. These agents are effective in reducing the risk …
directed against mediators of type 2 immunity. These agents are effective in reducing the risk …
Long noncoding RNA LINC-PINT retards the abnormal growth of airway smooth muscle cells via regulating the microRNA-26a-5p/PTEN axis in asthma
P Gao, Y Ding, B Yin, H Gu - International Immunopharmacology, 2021 - Elsevier
Background Asthma is a chronic respiratory disease worldwide. This study aimed to explore
the functions of the long noncoding RNA LINC-PINT (LINC-PINT) in asthma and to …
the functions of the long noncoding RNA LINC-PINT (LINC-PINT) in asthma and to …
Treatable mechanisms in asthma
M Cazzola, J Ora, F Cavalli, P Rogliani… - Molecular Diagnosis & …, 2021 - Springer
Asthma is a heterogeneous condition, but firm identification of heterogeneity-focused
treatments is still lacking. Dividing patients into subgroups of asthma pheno-/endotypes …
treatments is still lacking. Dividing patients into subgroups of asthma pheno-/endotypes …
Molecular targets for biological therapies of severe asthma: focus on benralizumab and tezepelumab
SL Cheng - Life, 2021 - mdpi.com
Asthma is a heterogeneous respiratory disease characterized by usually reversible
bronchial obstruction, which is clinically expressed by different phenotypes driven by …
bronchial obstruction, which is clinically expressed by different phenotypes driven by …