Although much work has focused on the elucidation of somatic alterations that drive the
development of acute leukaemias and other haematopoietic diseases, it has become …

Juvenile myelomonocytic leukemia (JMML) is a rare pediatric leukemia characterized by
mutations in five canonical RAS pathway genes. The diagnosis is made by typical clinical …

Juvenile myelomonocytic leukemia is an overlapping myeloproliferative and
myelodysplastic disorder of early childhood. It is associated with a spectrum of diverse …

Casitas B-lineage lymphoma (CBL) encodes an E3 ubiquitin ligase and signaling adaptor
that regulates receptor and nonreceptor tyrosine kinases. Recurrent CBL mutations occur in …

Abstract Type 1 Chiari malformation (C1M) is characterized by cerebellar tonsillar herniation
of 3–5 mm or more, the frequency of which is presumably much higher than one in 1000 …

In recent years CMML has received increased attention as the most commonly observed
MDS/MPN overlap syndrome. Renewed interest has occurred in part due to widespread …

Juvenile myelomonocytic leukaemia (JMML), a rare clonal haematopoietic disorder of
childhood, is characterised as a myelodysplastic/myeloproliferative neoplasm. Despite …

Myeloid neoplasms with germline predisposition have recently been added as distinct
provisional entities in the 2017 revision of the World Health Organization's classification of …

The clinical and laboratory criteria for hemophagocytic lymphohistiocytosis should be taken
into account during the juvenile myelomonocytic leukemia diagnosis, specifically in CBL …

KMT2A (MLL) abnormalities are common in leukemias of various lineages. Specifically,
KMT2A chromosomal rearrangements are present in about 5% to 15% of all adolescents …