[HTML][HTML] Biological and clinical consequences of integrin binding via a rogue RGD motif in the SARS CoV-2 spike protein
L Makowski, W Olson-Sidford, J W. Weisel - Viruses, 2021 - mdpi.com
Although ACE2 (angiotensin converting enzyme 2) is considered the primary receptor for
CoV-2 cell entry, recent reports suggest that alternative pathways may contribute. This paper …
CoV-2 cell entry, recent reports suggest that alternative pathways may contribute. This paper …
[HTML][HTML] Syndecans and their synstatins: targeting an organizer of receptor tyrosine kinase signaling at the cell-matrix interface
AC Rapraeger - Frontiers in Oncology, 2021 - frontiersin.org
Receptor tyrosine kinases (RTKs) and integrins have well-established roles in tumor cell
proliferation, invasion and survival, often functioning in a coordinated fashion at sites of cell …
proliferation, invasion and survival, often functioning in a coordinated fashion at sites of cell …
Talin-dependent integrin activation is required for endothelial proliferation and postnatal angiogenesis
FE Pulous, JC Carnevale, Z Al-Yafeai, BH Pearson… - Angiogenesis, 2021 - Springer
Integrin activation contributes to key blood cell functions including adhesion, proliferation
and migration. An essential step in the cell signaling pathway that activates integrin requires …
and migration. An essential step in the cell signaling pathway that activates integrin requires …
Targeted therapy to β3 integrin reduces chemoresistance in breast cancer bone metastases
Breast cancer bone metastases are common and incurable. Tumoral integrin β3 (β3)
expression is induced through interaction with the bone microenvironment. Although β3 is …
expression is induced through interaction with the bone microenvironment. Although β3 is …
[PDF][PDF] Extracellular PKM2 facilitates organ-tissue fibrosis progression
Persistent activation of fibroblasts and resistance of myofibroblasts to turnover play important
roles in organ-tissue fibrosis development and progression. The mechanism that mediates …
roles in organ-tissue fibrosis development and progression. The mechanism that mediates …
[HTML][HTML] Vascular cell-matrix adhesion in development and cancer
C Arapatzi, G Rouni, V Kostourou - The International Journal of …, 2021 - ijdb.ehu.eus
The development and homeostasis of vertebrate organisms depend on the “tree of life”, in
other words, the intricate network of vascular tubes composed of endothelial cells attached …
other words, the intricate network of vascular tubes composed of endothelial cells attached …
[HTML][HTML] Prolyl 3-hydroxylase 2 is a molecular player of angiogenesis
P Pignata, I Apicella, V Cicatiello, C Puglisi… - International Journal of …, 2021 - mdpi.com
Prolyl 3-hydroxylase 2 (P3H2) catalyzes the post-translational formation of 3-hydroxyproline
on collagens, mainly on type IV. Its activity has never been directly associated to …
on collagens, mainly on type IV. Its activity has never been directly associated to …
[PDF][PDF] Investigation of gender differences in the incidence of ascites and profile of gene expression in kidney tissue of broiler chickens.
S Malekshahdehi, SH Hafezian, G Rahimi-Mianji… - 2021 - ar.guilan.ac.ir
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[HTML][HTML] A bioinformatics perspective on the links between tetraspanin-enriched microdomains and cardiovascular pathophysiology
Background: Tetraspanins and integrins are integral membrane proteins. Tetraspanins
interact with integrins to modulate the dynamics of adhesion, migration, proliferation, and …
interact with integrins to modulate the dynamics of adhesion, migration, proliferation, and …
Tumor Vasculature
A multitude of imaging techniques are available for assessment of tissue vasculature on a
structural, functional, and molecular level. All these methods have been successfully used …
structural, functional, and molecular level. All these methods have been successfully used …