Central nervous system (CNS) injuries do not heal properly in contrast to normal tissue
repair, in which functional recovery typically occurs. The reason for this dichotomy in wound …

Automated flow cytometry (FC) data analysis tools for cell population identification and
characterization are increasingly being used in academic, biotechnology, pharmaceutical …

Monocyte homing to the liver and adhesion to the liver sinusoidal endothelial cells (LSECs)
are key elements in nonalcoholic steatohepatitis (NASH) pathogenesis. We reported …

For treatment and diagnosis of cancer, antibodies have proven their value and now serve as
a first line of therapy for certain cancers. A unique class of antibody fragments called …

Neoantigen-specific T cells are strongly implicated as being critical for effective immune
checkpoint blockade treatment (ICB)(eg, anti–PD-1 and anti–CTLA-4) and are being …

Mouse hematopoietic tissues contain abundant tissue-resident macrophages that support
immunity, hematopoiesis, and bone homeostasis. A systematic strategy to characterize …

The development and functional potential of metazoan cells is dependent on combinatorial
roles of transcriptional enhancers and promoters. Macrophages provide exceptionally …

Rationale: Idiopathic pulmonary fibrosis (IPF) is a progressive inflammatory lung disease
without effective molecular markers of disease activity or treatment responses. Monocyte …

The earliest reported observations on neutrophils date from 1879 to 1880, when Paul
Ehrlich utilized a set of coal tar dyes to interrogate differential staining properties of the …

Neutrophils have historically been considered a singular, terminally-differentiated cell
population, replete with pre-formed granules, poised to react quickly, aggressively, and …