The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives

C d'Enfert, AK Kaune, LR Alaban… - FEMS microbiology …, 2021 - academic.oup.com
Candida albicans is a major fungal pathogen of humans. It exists as a commensal in the oral
cavity, gut or genital tract of most individuals, constrained by the local microbiota, epithelial …

Immune Sensing of Candida albicans

E Bojang, H Ghuman, P Kumwenda, RA Hall - Journal of Fungi, 2021 - mdpi.com
Candida albicans infections range from superficial to systemic and are one of the leading
causes of fungus-associated nosocomial infections. The innate immune responses during …

A small molecule produced by Lactobacillus species blocks Candida albicans filamentation by inhibiting a DYRK1-family kinase

J MacAlpine, M Daniel-Ivad, Z Liu, J Yano… - Nature …, 2021 - nature.com
The fungus Candida albicans is an opportunistic pathogen that can exploit imbalances in
microbiome composition to invade its human host, causing pathologies ranging from vaginal …

3D printed clotrimazole intravaginal ring for the treatment of recurrent vaginal candidiasis

M Tiboni, R Campana, E Frangipani… - International Journal of …, 2021 - Elsevier
Vulvovaginal candidiasis is a vaginal infection caused by the fungal pathogen Candida
albicans that, most commonly, affects women of reproductive age. Its first-line treatment …

Prevalence, species distribution and antifungal susceptibility of Candida albicans causing vaginal discharge among symptomatic non-pregnant women of …

DN Anh, DN Hung, TV Tien, VN Dinh, VT Son… - BMC infectious …, 2021 - Springer
Background Vaginal candidiasis is frequent in women of reproductive age. Accurate
identification Candida provides helpful information for successful therapy and epidemiology …

[HTML][HTML] Does probiotics work for bacterial vaginosis and vulvovaginal candidiasis

Y Han, Q Ren - Current opinion in pharmacology, 2021 - Elsevier
The different Lactobacillus strains of probiotics have been applied to the treatment and
prevention of bacterial vaginosis and vulvovaginal candidiasis. The experimental data …

Bioadhesive-Thermosensitive In Situ Vaginal Gel of the Gel Flake-Solid Dispersion of Itraconazole for Enhanced Antifungal Activity in the Treatment of Vaginal …

AD Permana, E Utomo, MR Pratama… - … Applied Materials & …, 2021 - ACS Publications
The poor solubility of itraconazole (ITZ) has limited its efficacy in the treatment of vaginal
candidiasis. Accordingly, the improvement of ITZ solubility using a solid dispersion …

Candida glabrata Antifungal Resistance and Virulence Factors, a Perfect Pathogenic Combination

MG Frías-De-León, R Hernández-Castro… - Pharmaceutics, 2021 - mdpi.com
In recent years, a progressive increase in the incidence of invasive fungal infections (IFIs)
caused by Candida glabrata has been observed. The objective of this literature review was …

Schiff-base silver nanocomplexes formation on natural biopolymer coated mesoporous silica contributed to the improved curative effect on infectious microbes

L Cai, Y Huang, Y Duan, Q Liu, Q Xu, J Jia, J Wang… - Nano Research, 2021 - Springer
Infectious microbes that spread easily in healthcare facilities remain as the severe threat for
the public health, especially among immunocompromised populations. Given the intricate …

[HTML][HTML] Chitosan-based systems aimed at local application for vaginal infections

VHS Araujo, MPC de Souza, GC Carvalho… - Carbohydrate …, 2021 - Elsevier
Vaginal administration is a promising route for the local treatment of infectious vaginal
diseases since it can bypass the first-pass metabolism, drug interactions, and adverse …