Adenosine monophosphate‐activated protein kinase (AMPK) is a cellular energy sensor
activated during energy stress that plays a key role in maintaining energy homeostasis. This …

Heart failure is one of the leading causes of death and disability worldwide. Left ventricle
remodeling, fibrosis, and ischemia/reperfusion injury all contribute to the deterioration of …

Myocardial infarction (MI) is accompanied by severe energy deprivation and extensive
epigenetic changes. However, how energy metabolism and chromatin modifications are …

The myocardium is capable of utilizing different energy substrates, which is referred to as
“metabolic flexibility.” This process assures ATP production from fatty acids, glucose, lactate …

G protein-coupled receptors (GPCRs) comprise the largest family of transmembrane
receptors and their signal transduction is tightly regulated by GPCR kinases (GRKs) and β …

This study evaluated if the cardioprotective effect of Exendin-4 against ischemia/reperfusion
(I/R) injury in male rats involves modulation of AMPK and sirtuins. Adult male rats were …

The α1-adrenergic receptors (ARs) are G-protein coupled receptors that bind the
endogenous catecholamines, norepinephrine, and epinephrine. They play a key role in the …

Metabolic modulation is a promising therapeutic approach to prevent adverse remodeling of
the ischemic heart. Because little is known about the involvement of long non-coding RNAs …

Heart failure (HF) is a global public health problem with high morbidity and mortality. A large
number of studies have shown that HF is caused by severe energy metabolism disorders …

Pulmonary hypertension (PH) is a debilitating and life-threatening disease characterized by
increased blood pressure within the pulmonary arteries. Adenosine monophosphate …