Type 1 diabetes (T1D) is an autoimmune disease in which T cells attack and destroy the
insulin-producing β cells in the pancreatic islets. Genetic and environmental factors increase …

The pathogenesis of hyperglycemia observed in most forms of diabetes is intimately tied to
the islet β cell. Impairments in propeptide processing and secretory function, along with the …

Following type 1 diabetes (T1D) diagnosis, declining C-peptide levels reflect deteriorating β
cell function. However, the precise C-peptide levels that indicate protection from severe …

Objective The proinsulin to C-peptide (PI: C) ratio is reputedly a biomarker of β-cell
endoplasmic reticulum (ER) stress. Objective This study examined the natural history of the …

One hundred years after its discovery, insulin remains the life-saving therapy for many
patients with diabetes. It has been a 100-years-old success story thanks to the fact that …

Context High-residual C-peptide in longer-duration type 1 diabetes (T1D) is associated with
fewer hypoglycemic events and reduced glycemic variability. Little is known about the …

One century after the discovery of insulin, the French Health regulations have just authorized
the reimbursement for islet transplantation. Intraportal islet allotransplantation from a …

Summary Type 1 diabetes (T1D) is an autoimmune disease characterised by T cell-
mediated destruction of the insulin-producing β cells in the pancreas. Similar to other …

Diabetic retinopathy (DR) is a potentially devastating complication of diabetes because it
puts patients at risk of blindness. Diabetes is a common cause of blindness in the US and …

Backgraund: It believed that autoimmune process maintained only during the first 5 years of
diabetes mellitus type 1 (T1D). Recently scientists discovered the high levels of islet …