Guidelines for the treatment of chronic spontaneous urticaria (CSU) recommend the use of
the IgE-targeted biologic omalizumab in patients with antihistamine-refractory disease. The …

Urticaria is a type of skin disease characterized by rapid onset of hives (superficial dermis
edema, erythema, pruritus, or burning sensation). According to whether the natural course …

Basophil testing is the most effective single approach for diagnosing type-IIb autoimmune
chronic spontaneous urticaria (TIIbaiCSU). A positive basophil test has been linked to long …

Introduction: Chronic spontaneous urticaria (CSU) is a frequent disorder in which activation
of effector cells and histamine release can be induced via several distinct pathogenetic …

2 Chronic spontaneous urticaria (CSU) is characterized by the spontaneous appearance of
wheals, 3 angioedema or both for more than 6 weeks1. CSU signs and symptoms, albeit not …

Background Omalizumab is effective in patients with chronic spontaneous urticaria (CSU)
although its mechanism of action is poorly understood. Several studies reported that …

Background The mechanisms underlying disease pathogenesis in chronic spontaneous
urticaria (CSU) and improvement with omalizumab are incompletely understood. Objectives …

Abstract “Looking forward” in CU is a challenging chapter. Chronic Urticaria (CU) is a
heterogeneous condition that causes significant morbidity. The most recent pathogenic and …

Chronic urticaria, a common mast cell driven disease, has been considered so far an
underestimated and difficult to treat disease, very often resulting in high physical …

Omalizumab is a humanized mouse monoclonal IgG1 antibody directed against the third
heavy chain domain of IgE. It has been approved for moderate to severe asthma since 2003 …