Oxidative stress (OxS) is considered a major factor in the pathophysiology of inflammatory
chronic liver diseases, including non-alcoholic liver disease (NAFLD). Chronic impairment of …

Sterol Regulatory Element Binding Protein-1c is a transcription factor that controls the
synthesis of lipids from glucose in the liver, a process which is of utmost importance for the …

The endoplasmic reticulum (ER) hosts linear polypeptides and fosters natural folding of
proteins through ER-residing chaperones and enzymes. Failure of the ER to align and …

Simple Summary Non-alcoholic steatohepatitis (NASH) is a common liver disease,
characterized by fatty liver, chronic tissue damage, inflammation and fibrosis. NASH greatly …

Adaptive thermogenesis is essential for survival, and therefore is tightly regulated by a
central neural circuit. Here, we show that microRNA (miR)-33 in the brain is indispensable …

DNA damage triggers the cellular adaptive response to arrest proliferation and repair DNA
damage; when damage is too severe to be repaired, apoptosis is initiated to prevent the …

Transcription factors (TFs) are known to be involved in regulating the expression of several
classes of genes during folliculogenesis. However, the regulatory role of TFs during …

Decreasing circulating low-density lipoprotein (LDL) cholesterol levels leads to decreased
risk of cardiovascular diseases. Natural compounds are capable of lowering LDL …

Hepatocellular carcinoma (HCC), the most common type of primary liver cancer provides the
prototypical example of an obesity-related cancer. The obesity epidemic gave rise to an …

Results Calreticulin deficiency disrupts lipid homeostasis. Calreticulin deficiency in mice is
embryonic lethal11 but cardiac-specific expression of constitutively active calcineurin …