Hepatic, pancreatic, and biliary (HPB) organoids are powerful tools for studying
development, disease, and regeneration. As organoid research expands, the need for clear …

Liver fibrosis refers to the process underlying the development of chronic liver diseases,
wherein liver cells are repeatedly destroyed and regenerated, which leads to an excessive …

Hepatocellular carcinoma (HCC) is one of the most lethal tumors worldwide. This study aims
to address the lack of faithful and available in vitro models for patient-specific drug screening …

Microphysiology systems (MPS), also called organs-on-chips and tissue chips, are
miniaturized functional units of organs constructed with multiple cell types under a variety of …

The hepatic mesenchyme has been studied extensively in the context of liver fibrosis;
however, much less is known regarding the role of mesenchymal cells during liver …

Clinical transplants of hematopoietic stem cells (HSC) can provide a lifesaving therapy for
many hematological diseases; however, therapeutic applications are hampered by donor …

Hepatocellular carcinomas (HCCs) are highly heterogeneous malignancies with different
risk factors, including alcohol abuse, chronic hepatitis B virus (HBV) and hepatitis C virus …

The past decade has seen many advancements in the development of three-dimensional
(3D) in vitro models in pharmaceutical sciences and industry. Specifically, organoids present …

Organoids are tiny, self-organized, three-dimensional tissue cultures that are derived from
the differentiation of stem cells. The growing interest in the use of organoids arises from their …

Liver plays a critical role in drug metabolism and nowadays multi-cellular culture systems
aiming at imitating liver-specific morphology and functionality are advancing robustly …