Forming the inner layer of the vascular system, endothelial cells (ECs) facilitate a multitude
of crucial physiological processes throughout the body. Vascular ECs enable the vessel wall …

Despite the ever-increasing prevalence of non-alcoholic fatty liver disease (NAFLD), the
etiology and pathogenesis remain poorly understood. This is due, in part, to the liver's …

The liver is an essential organ that is critical for the removal of toxins, the production of
proteins, and the maintenance of metabolic homeostasis. Behind each liver functional unit …

Spatial metabolomics can reveal intercellular heterogeneity and tissue organization. Here
we report on the spatial single nuclear metabolomics (SEAM) method, a flexible platform …

The aim of this review is to give an outline of the blood clearance function of the liver
sinusoidal endothelial cells (LSECs) in health and disease. Lining the hundreds of millions …

Background & Aims The multiple vital functions of the human liver are performed by highly
specialised parenchymal and non-parenchymal cells organised in complex collaborative …

Background Dysfunction of liver sinusoidal endothelial cells (LSECs) is permissive for the
progression of liver fibrosis and cirrhosis and responsible for its clinical complications. Here …

Abstract Development of liver fibrosis results in drastic changes in the liver
microenvironment, which in turn accelerates disease progression. Although the pathological …

Liver sinusoids are lined by liver sinusoidal endothelial cells (LSEC), which represent
approximately 15 to 20% of the liver cells, but only 3% of the total liver volume. LSEC have …

Ischemia–reperfusion injury (IRI) remains the major reason for impaired donor graft function
and increased mortality post-liver transplantation. The mechanism of IRI involves multiple …