Vascular endothelial cells: heterogeneity and targeting approaches

JK Hennigs, C Matuszcak, M Trepel, J Körbelin - Cells, 2021 - mdpi.com
Forming the inner layer of the vascular system, endothelial cells (ECs) facilitate a multitude
of crucial physiological processes throughout the body. Vascular ECs enable the vessel wall …

[HTML][HTML] Liver zonation–revisiting old questions with new technologies

RP Cunningham, N Porat-Shliom - Frontiers in physiology, 2021 - frontiersin.org
Despite the ever-increasing prevalence of non-alcoholic fatty liver disease (NAFLD), the
etiology and pathogenesis remain poorly understood. This is due, in part, to the liver's …

The immune niche of the liver

ML Cheng, D Nakib, CT Perciani… - Clinical …, 2021 - portlandpress.com
The liver is an essential organ that is critical for the removal of toxins, the production of
proteins, and the maintenance of metabolic homeostasis. Behind each liver functional unit …

SEAM is a spatial single nuclear metabolomics method for dissecting tissue microenvironment

Z Yuan, Q Zhou, L Cai, L Pan, W Sun, S Qumu, S Yu… - Nature …, 2021 - nature.com
Spatial metabolomics can reveal intercellular heterogeneity and tissue organization. Here
we report on the spatial single nuclear metabolomics (SEAM) method, a flexible platform …

[HTML][HTML] The scavenger function of liver sinusoidal endothelial cells in health and disease

S Bhandari, AK Larsen, P McCourt… - Frontiers in …, 2021 - frontiersin.org
The aim of this review is to give an outline of the blood clearance function of the liver
sinusoidal endothelial cells (LSECs) in health and disease. Lining the hundreds of millions …

[HTML][HTML] Single-cell RNA sequencing of human liver reveals hepatic stellate cell heterogeneity

VL Payen, A Lavergne, NA Sarika, M Colonval, L Karim… - Jhep Reports, 2021 - Elsevier
Background & Aims The multiple vital functions of the human liver are performed by highly
specialised parenchymal and non-parenchymal cells organised in complex collaborative …

[HTML][HTML] Single-cell transcriptomics reveals zone-specific alterations of liver sinusoidal endothelial cells in cirrhosis

T Su, Y Yang, S Lai, J Jeong, Y Jung… - Cellular and molecular …, 2021 - Elsevier
Background Dysfunction of liver sinusoidal endothelial cells (LSECs) is permissive for the
progression of liver fibrosis and cirrhosis and responsible for its clinical complications. Here …

Adipocyte fatty acid binding protein promotes the onset and progression of liver fibrosis via mediating the crosstalk between liver sinusoidal endothelial cells and …

X Wu, L Shu, Z Zhang, J Li, J Zong… - Advanced …, 2021 - Wiley Online Library
Abstract Development of liver fibrosis results in drastic changes in the liver
microenvironment, which in turn accelerates disease progression. Although the pathological …

Critical role of LSEC in post-hepatectomy liver regeneration and failure

M De Rudder, A Dili, P Stärkel, IA Leclercq - International journal of …, 2021 - mdpi.com
Liver sinusoids are lined by liver sinusoidal endothelial cells (LSEC), which represent
approximately 15 to 20% of the liver cells, but only 3% of the total liver volume. LSEC have …

Resolving the graft ischemia-reperfusion injury during liver transplantation at the single cell resolution

L Wang, J Li, S He, Y Liu, H Chen, S He, M Yin… - Cell death & …, 2021 - nature.com
Ischemia–reperfusion injury (IRI) remains the major reason for impaired donor graft function
and increased mortality post-liver transplantation. The mechanism of IRI involves multiple …