Genetic susceptibility of hypertension‐induced kidney disease
Hypertension is the second leading cause of end‐stage renal disease (ESRD) after diabetes
mellitus. The significant differences in the incidence of hypertensive ESRD between different …
mellitus. The significant differences in the incidence of hypertensive ESRD between different …
20-HETE-promoted cerebral blood flow autoregulation is associated with enhanced pericyte contractility
We previously reported that deficiency in 20-HETE or CYP4A impaired the myogenic
response and autoregulation of cerebral blood flow (CBF) in rats. The present study …
response and autoregulation of cerebral blood flow (CBF) in rats. The present study …
Emerging insights into chronic renal disease pathogenesis in hypertension from human and animal genomic studies
The pathogenic links between elevated blood pressure and chronic kidney disease remain
obscure. This article examines progress in population genetics and in animal models of …
obscure. This article examines progress in population genetics and in animal models of …
Role of γ-adducin in actin cytoskeleton rearrangements in podocyte pathophysiology
We recently reported that the enhanced susceptibility to chronic kidney disease (CKD) in the
fawn-hooded hypertensive (FHH) rat is caused, at least in part, by a mutation in γ-adducin …
fawn-hooded hypertensive (FHH) rat is caused, at least in part, by a mutation in γ-adducin …
Knockout of γ-adducin promotes NG-nitro-L-arginine-methyl-ester–induced hypertensive renal injury
Previous studies identified a region on chromosome 1 associated with NG-nitro-L-arginine
methyl ester (L-NAME) hypertension-induced renal disease in fawn-hooded hypertensive …
methyl ester (L-NAME) hypertension-induced renal disease in fawn-hooded hypertensive …
20-HETE-promoted cerebral blow flow autoregulation is associated with enhanced α-smooth muscle actin positive cerebrovascular pericyte contractility
Y Liu, H Zhang, T Yu, X Fang, JJ Ryu, B Zheng, Z Chen… - bioRxiv, 2021 - biorxiv.org
We previously reported that deficiency in 20-HETE or CYP4A impaired the myogenic
response and autoregulation of cerebral blood flow (CBF) in rats. The present study …
response and autoregulation of cerebral blood flow (CBF) in rats. The present study …
Impaired Renal Hemodynamics and Glomerular Hyperfiltration Contribute to Hypertension-Induced Renal Injury in γ-Adducin Knockout Rats
L Fan - 2021 - search.proquest.com
Hypertension is a major risk factor for chronic kidney disease (CKD) and end-stage renal
disease (ESRD); it accounts for 76% of the newly diagnosed cases. The treatment for renal …
disease (ESRD); it accounts for 76% of the newly diagnosed cases. The treatment for renal …