An insight into GPCR and G-proteins as cancer drivers
PK Chaudhary, S Kim - Cells, 2021 - mdpi.com
G-protein-coupled receptors (GPCRs) are the largest family of cell surface signaling
receptors known to play a crucial role in various physiological functions, including tumor …
receptors known to play a crucial role in various physiological functions, including tumor …
Mutations in G protein–coupled receptors: mechanisms, pathophysiology and potential therapeutic approaches
T Schöneberg, I Liebscher - Pharmacological reviews, 2021 - ASPET
There are approximately 800 annotated G protein–coupled receptor (GPCR) genes, making
these membrane receptors members of the most abundant gene family in the human …
these membrane receptors members of the most abundant gene family in the human …
Alcohol use disorders and ADHD
M Luderer, JAR Quiroga, SV Faraone… - Neuroscience & …, 2021 - Elsevier
Despite a growing literature on the complex bidirectional relationship of ADHD and
substance use, reviews specifically focusing on alcohol are scarce. ADHD and AUD show a …
substance use, reviews specifically focusing on alcohol are scarce. ADHD and AUD show a …
Adolescent attention-deficit/hyperactivity disorder: understanding teenage symptom trajectories
Symptoms of attention-deficit/hyperactivity disorder (ADHD) run a variable course through
adolescence. While most affected individuals show some improvement, particularly of …
adolescence. While most affected individuals show some improvement, particularly of …
Protein interaction networks: centrality, modularity, dynamics, and applications
In the post-genomic era, proteomics has achieved significant theoretical and practical
advances with the development of high-throughput technologies. Especially the rapid …
advances with the development of high-throughput technologies. Especially the rapid …
An epigenetic, transgenerational model of increased mental health disorders in children, adolescents and young adults
AP Monaco - European Journal of Human Genetics, 2021 - nature.com
Prevalence rates of mental health disorders in children and adolescents have increased two
to threefold from the 1990s to 2016. Some increase in prevalence may stem from changing …
to threefold from the 1990s to 2016. Some increase in prevalence may stem from changing …
Pathogenic GRM7 mutations associated with neurodevelopmental disorders impair axon outgrowth and presynaptic terminal development
J Song, M Kang, D Park, S Park, S Lee… - Journal of …, 2021 - Soc Neuroscience
Metabotropic glutamate receptor 7 (mGlu7) is an inhibitory heterotrimeric G-protein-coupled
receptor that modulates neurotransmitter release and synaptic plasticity at presynaptic …
receptor that modulates neurotransmitter release and synaptic plasticity at presynaptic …
[HTML][HTML] A GRM7 mutation associated with developmental delay reduces mGlu7 expression and produces neurological phenotypes
NM Fisher, A AlHashim, AB Buch, H Badivuku… - JCI insight, 2021 - ncbi.nlm.nih.gov
The metabotropic glutamate receptor 7 (mGlu 7) is a G protein–coupled receptor that has
been recently linked to neurodevelopmental disorders. This association is supported by the …
been recently linked to neurodevelopmental disorders. This association is supported by the …
Peripheral biomarkers of attention-deficit hyperactivity disorder: Current status and future perspective
N Takahashi, K Ishizuka, T Inada - Journal of Psychiatric Research, 2021 - Elsevier
Attention-deficit hyperactivity disorder (ADHD) is one of the most common
neurodevelopmental disorders, characterized by a persistent pattern of inattention …
neurodevelopmental disorders, characterized by a persistent pattern of inattention …
Detection of copy number variation associated with ventriculomegaly in fetuses using single nucleotide polymorphism arrays
H Xue, A Yu, N Lin, X Chen, M Lin, Y Wang, H Huang… - Scientific reports, 2021 - nature.com
Etiopathogenesis of fetal ventriculomegaly is poorly understood. Associations between fetal
isolated ventriculomegaly and copy number variations (CNVs) have been previously …
isolated ventriculomegaly and copy number variations (CNVs) have been previously …