Rationalizing the therapeutic potential of apigenin against cancer

SA Ahmed, D Parama, E Daimari, S Girisa, K Banik… - Life sciences, 2021 - Elsevier
Background Despite the remarkable advances made in the diagnosis and treatment of
cancer during the past couple of decades, it remains the second largest cause of mortality in …

Cytotoxicity of apigenin toward multiple myeloma cell lines and suppression of iNOS and COX-2 expression in STAT1-transfected HEK293 cells

AN Adham, S Abdelfatah, AM Naqishbandi… - Phytomedicine, 2021 - Elsevier
Background Apigenin is one of the most abundant dietary flavonoids that possesses multiple
bio-functions. Purpose This study was designed to determine the influence of apigenin on …

Protective effects of apigenin on altered lipid peroxidation, inflammation, and antioxidant factors in methotrexate-induced hepatotoxicity

M Goudarzi, M Kalantar, E Sadeghi… - Naunyn-Schmiedeberg's …, 2021 - Springer
Methotrexate (MTX) is used as an effective chemotherapeutic agent against autoimmune
diseases and tumors. Oxidative stress and inflammation are involved in the pathogenesis of …

Apigenin alleviates methotrexate-induced liver and kidney injury in mice

F Sahindokuyucu-Kocasari, Y Akyol… - Human & …, 2021 - journals.sagepub.com
Methotrexate (MTX) is a drug used in the treatment of various types of cancer and
inflammatory diseases, but its clinical use has been restricted due to its toxicity. Apigenin …

Green chemistry approaches to the synthesis of flavonoids

Y Murti, D Pathak, K Pathak - Current Organic Chemistry, 2021 - ingentaconnect.com
In nature, flavonoids constitute a relatively diverse family of aromatic molecules such as
flavones, flavonols, flavanones, isoflavone, chalcones, and their derivatives. Natural and …

Induced cell death as a possible pathway of antimutagenic action

NV Eremina, AK Zhanataev, AD Durnev - Bulletin of experimental biology …, 2021 - Springer
The existing concepts of antimutagenesis are briefly reviewed. Published reports on
antimutagenic and proapoptotic properties of some polyphenols and compounds of other …

Synergistic effect of Betulinic acid, Apigenin and Skimmianine (BASk) in high cholesterol diet rabbit: Involvement of CD36-TLR2 signaling pathway

V Sabu, S Krishnan, J Peter, IS Aswathy, SSL Preethi… - Cytokine, 2021 - Elsevier
Background Progression of chronic inflammatory disease, atherosclerosis is a multifactorial
process. Cluster of differentiation 36 (CD36) mediated downstream activation of Toll like …

[PDF][PDF] Progression of hepatic encephalopathy induced by bile duct ligation versus thioacetamide in rats: Regulatory role of apigenin

AM Fayez, DF Mansour, DO Saleh - Journal of Applied …, 2021 - japsonline.com
Hepatic encephalopathy (HE) is the decline in brain functions due to liver insufficiency. A
high mortality rate was reported due to the rapid progression of HE from covert to overt …

[PDF][PDF] Индуцируемая клеточная гибель как возможный путь антимутагенного воздействия

НВ Еремина, АК Жанатаев… - … биологии и медицины, 2021 - researchgate.net
Адрес для корреспонденции: addurney (amail. ru. Дур-нев АД alois 10.47056/0365-06 15—
2021-171-1-4-22 литов с молекулой ДНК, репарацию повреж-дений ДНК. Каждая из …

[HTML][HTML] Bioactive compounds from herbal medicine targeting multiple myeloma

C Cotoraci, A Ciceu, A Sasu, E Miutescu… - Applied Sciences, 2021 - mdpi.com
Multiple myeloma (MM) is one of the most widespread hematological cancers. It is
characterized by a clonal proliferation of malignant plasma cells in the bone marrow and by …