Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Multi-omics approaches have become a reality in both large genomics projects and small
laboratories. However, the multi-omics research community still faces a number of issues …

Here we report the generation of a multimodal cell census and atlas of the mammalian
primary motor cortex as the initial product of the BRAIN Initiative Cell Census Network …

Single-cell transcriptomics can provide quantitative molecular signatures for large, unbiased
samples of the diverse cell types in the brain,–. With the proliferation of multi-omics datasets …

Glutamate (Glu) is the primary excitatory transmitter in the mammalian brain. But, we know
little about the evolutionary history of this adaptation, including the selection of l-glutamate …

Recent developments have revolutionized the study of biomolecules. Among them are
molecular markers, amplification and sequencing of nucleic acids. The latter is classified into …

The inherent heterogeneity of individual cells in cell populations plays significant roles in
disease development and progression, which is critical for disease diagnosis and treatment …

In the mammalian brain, cortical interneurons (INs) are a highly diverse group of cells. A key
neurophysiological question concerns how each class of INs contributes to cortical circuit …

How neurons in the medial prefrontal cortex broadcast stress-relevant information to
subcortical brain sites to regulate cocaine relapse remains unclear. The lateral habenula …

Single-cell and single-nucleus RNA sequencing (sc/snRNA-seq) technologies have
enhanced the understanding of the molecular pathogenesis of neurodegenerative …