Genistein is an isoflavone first isolated from the brooming plant Dyer's Genista tinctoria L.
and is widely distributed in the Fabaceae family. As an isoflavone, mammalian genistein …

Transcription factors (TFs) represent key biological players in diseases including cancer,
autoimmunity, diabetes and cardiovascular disease. However, outside nuclear receptors …

As a phenolic acid compound, caffeic acid (CA) can be isolated from different sources such
as tea, wine and coffee. Caffeic acid phenethyl ester (CAPE) is naturally occurring derivative …

Since its discovery, the Janus kinase-signal transduction and activation of transcription (JAK-
STAT) pathway has become recognized as a central mediator of widespread and varied …

Signal transducer and activator of transcription 3 (STAT3) is one of the crucial transcription
factors, responsible for regulating cellular proliferation, cellular differentiation, migration …

Cancer is one of the world's biggest healthcare burdens and despite the current
advancements made in treatment plans, the outcomes for oncology patients have yet to …

Background Despite the remarkable advances made in the diagnosis and treatment of
cancer during the past couple of decades, it remains the second largest cause of mortality in …

Cancer is a major public health concern due to high mortality and poor quality of life of
patients. Despite the availability of advanced therapeutic interventions, most treatment …

Tumor cells undergo invasion and metastasis through epithelial‐to‐mesenchymal cell
transition (EMT) by activation of alterations in extracellular matrix (ECM) protein‐encoding …

Metformin is a first-line drug in the treatment of type-2 diabetes mellitus (T2DM). In addition
to its antigluconeogenic and insulin-sensitizing properties, metformin has emerged as a …