Hypoxia/HIF modulates immune responses
Y Chen, T Gaber - Biomedicines, 2021 - mdpi.com
Oxygen availability varies throughout the human body in health and disease. Under
physiological conditions, oxygen availability drops from the lungs over the blood stream …
physiological conditions, oxygen availability drops from the lungs over the blood stream …
The ORF8 protein of SARS-CoV-2 mediates immune evasion through down-regulating MHC-Ι
COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has
become a global pandemic and has claimed over 2 million lives worldwide. Although the …
become a global pandemic and has claimed over 2 million lives worldwide. Although the …
Beyond energy storage: roles of glycogen metabolism in health and disease
H Zhang, J Ma, K Tang, B Huang - The FEBS Journal, 2021 - Wiley Online Library
Beyond storing and supplying energy in the liver and muscles, glycogen also plays critical
roles in cell differentiation, signaling, redox regulation, and stemness under various …
roles in cell differentiation, signaling, redox regulation, and stemness under various …
Prediction and mitigation of mutation threats to COVID-19 vaccines and antibody therapies
Antibody therapeutics and vaccines are among our last resort to end the raging COVID-19
pandemic. They, however, are prone to over 5000 mutations on the spike (S) protein …
pandemic. They, however, are prone to over 5000 mutations on the spike (S) protein …
Enforced PGC-1α expression promotes CD8 T cell fitness, memory formation and antitumor immunity
N Dumauthioz, B Tschumi, M Wenes, B Marti… - Cellular & molecular …, 2021 - nature.com
Memory CD8 T cells can provide long-term protection against tumors, which depends on
their enhanced proliferative capacity, self-renewal and unique metabolic rewiring to sustain …
their enhanced proliferative capacity, self-renewal and unique metabolic rewiring to sustain …
Prediction of differentially expressed microRNAs in blood as potential biomarkers for Alzheimer's disease by meta-analysis and adaptive boosting ensemble learning
Background Blood circulating microRNAs that are specific for Alzheimer's disease (AD) can
be identified from differentially expressed microRNAs (DEmiRNAs). However, non …
be identified from differentially expressed microRNAs (DEmiRNAs). However, non …
[HTML][HTML] HLA-A∗ 02: 01 restricted T cell receptors against the highly conserved SARS-CoV-2 polymerase cross-react with human coronaviruses
PA Nesterenko, J McLaughlin, BL Tsai, GB Sojo… - Cell Reports, 2021 - cell.com
Cross-reactivity and direct killing of target cells remain underexplored for severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2)-specific CD8+ T cells. Isolation of T cell …
respiratory syndrome coronavirus-2 (SARS-CoV-2)-specific CD8+ T cells. Isolation of T cell …
Immune response to SARS-CoV-2 infection in obesity and T2D: literature review
J Pérez-Galarza, C Prócel, C Cañadas, D Aguirre… - Vaccines, 2021 - mdpi.com
In December 2019, a novel coronavirus known as SARS-CoV-2 was first detected in Wuhan,
China, causing outbreaks of the coronavirus disease COVID-19 that has now spread …
China, causing outbreaks of the coronavirus disease COVID-19 that has now spread …
Using adjuvants to drive T cell responses for next-generation infectious disease vaccines
RR Rapaka, AS Cross, MA McArthur - Vaccines, 2021 - mdpi.com
Using adjuvants to drive features of T cell responses to vaccine antigens is an important
technological challenge in the design of new and improved vaccines against infections …
technological challenge in the design of new and improved vaccines against infections …
ApoB-Specific CD4+ T Cells in Mouse and Human Atherosclerosis
T Marchini, S Hansen, D Wolf - Cells, 2021 - mdpi.com
Atherosclerosis is a chronic inflammatory condition of the arterial wall that leads to the
formation of vessel-occluding plaques within the subintimal space of middle-sized and …
formation of vessel-occluding plaques within the subintimal space of middle-sized and …