E1 enzymes as therapeutic targets in cancer
SH Barghout, AD Schimmer - Pharmacological reviews, 2021 - ASPET
Post-translational modifications of cellular substrates with ubiquitin and ubiquitin-like
proteins (UBLs), including ubiquitin, SUMOs, and neural precursor cell–expressed …
proteins (UBLs), including ubiquitin, SUMOs, and neural precursor cell–expressed …
PR-619, a general inhibitor of deubiquitylating enzymes, diminishes cisplatin resistance in urothelial carcinoma cells through the suppression of c-Myc: an in vitro and …
Cisplatin-based chemotherapy is the standard treatment for bladder urothelial carcinoma
(UC). Most patients experience chemoresistance, the primary cause of treatment failure …
(UC). Most patients experience chemoresistance, the primary cause of treatment failure …
NPRL2 reduces the niraparib sensitivity of castration-resistant prostate cancer via interacting with UBE2M and enhancing neddylation
X Zhao, L Jiang, D Hu, Y Tang, G Zhao, X Du… - Experimental Cell …, 2021 - Elsevier
In this study, we explored the regulatory effects of nitrogen permease regulator 2-like
(NPRL2) on niraparib sensitivity, a PARP inhibitor (PARPi) in castrate-resistant prostate …
(NPRL2) on niraparib sensitivity, a PARP inhibitor (PARPi) in castrate-resistant prostate …
[HTML][HTML] THZ1, a covalent CDK7 inhibitor, enhances gemcitabine-induced cytotoxicity via suppression of Bcl-2 in urothelial carcinoma
KL Kuo, WC Lin, SH Liu, FS Hsu, Y Kuo… - American Journal of …, 2021 - ncbi.nlm.nih.gov
Chemotherapy with gemcitabine plus cisplatin remains the mainstay of treatment for
metastatic urothelial carcinoma (UC); however, drug resistance occurs in most patients and …
metastatic urothelial carcinoma (UC); however, drug resistance occurs in most patients and …
Inhibiting Neddylation with MLN4924 Suppresses Growth and Delays Multicellular Development in Dictyostelium discoideum
Neddylation is a post-translational modification that is essential for a variety of cellular
processes and is linked to many human diseases including cancer, neurodegeneration, and …
processes and is linked to many human diseases including cancer, neurodegeneration, and …