Health is usually defined as the absence of pathology. Here, we endeavor to define health
as a compendium of organizational and dynamic features that maintain physiology. The …

The hypothalamic-pituitary-adrenal (HPA) axis is involved in the pathophysiology of many
neuropsychiatric disorders. Increased HPA axis activity can be observed during chronic …

Cannabidiol (CBD) is the most abundant non-psychoactive component of cannabis; it
displays a very low affinity for cannabinoid receptors, facilitates endocannabinoid signaling …

Background Selective serotonin reuptaker inhibitors, including fluoxetine, are widely studied
and prescribed antidepressants, while their exact molecular and cellular mechanism are yet …

Given its chronicity, contribution to disability and morbidity, and prevalence of more than 2%,
the effective treatment, and prevention of bipolar disorder represents an area of significant …

Based on the findings in recent years, we summarize the therapeutic potential of vorinostat
(VOR), the first approved histone deacetylase (HDAC) inhibitor, in disorders of brain, and …

The adverse effects of stress on brain and behavior have long been known and well-studied,
with abundant evidence linking stress to, among other things, mood and anxiety disorders …

Migraine is the sixth most prevalent disease worldwide but the mechanisms that underlie
migraine chronicity are poorly understood. Cytoskeletal flexibility is fundamental to neuronal …

Depression is a neuropsychiatric disorder and has intrauterine developmental origins. This
study aimed to confirm the depression susceptibility in offspring rats induced by prenatal …

Depression is a highly prevalent, disabling, and often chronic illness that places substantial
burdens on patients, families, healthcare systems, and the economy. A substantial minority …