Triple negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, but
an effective targeted therapy has not been well-established so far. Considering the lack of …

Autophagy is a highly conserved metabolic process involved in the degradation of
intracellular components including proteins and organelles. Consequently, it plays a critical …

Sirtuin-3 (SIRT3) is an NAD+-dependent protein deacetylase localized primarily in the
mitochondria with many links to different types of human cancers. Autophagy, which is a …

Bromodomain-containing protein 4 (BRD4) is an attractive epigenetic target in human
cancers. Inhibiting the phosphorylation of BRD4 by casein kinase 2 (CK2) is a potential …

We herein report the identification, structural optimization, and structure–activity relationship
of thieno [2, 3-d] pyrimidine derivatives as a novel kind of selective vascular endothelial …

Autophagy is a critical cellular homeostatic mechanism, and its dysfunction is linked to
invasive breast carcinoma (BRCA). Recently, several omics methods have been applied to …

Targeted chemotherapy has become the forefront for cancer treatment in recent years. The
selective and specific features allow more effective treatment with reduced side effects. Most …

Due to its important roles in oncogenic signaling, AKT has been subjected to extensive drug
discovery efforts leading to small molecule inhibitors investigated in advanced clinical trials …

Co-targeting PARP and PI3K by PARP/PI3K dual inhibitors has been recognized as a
promising chemotherapeutic strategy for the treatment of triple negative breast cancer …

Background Among the common preventable cancers of women, cervical cancer has the
highest morbidity. It is curable if detected at an early stage. However, reliable diagnostic and …