Understanding how genotypes map onto phenotypes, fitness, and eventually organisms is
arguably the next major missing piece in a fully predictive theory of evolution. We refer to this …

Allostery is a fundamental biophysical mechanism that underlies cellular sensing, signaling,
and metabolism. Yet a quantitative understanding of allosteric genotype‐phenotype …

Functional biomolecules, such as RNA, encapsulated inside a protocellular membrane are
believed to have comprised a very early, critical stage in the evolution of life, since …

Most empirical studies of linkage disequilibrium (LD) study its magnitude, ignoring its sign.
Here, we examine patterns of signed LD in two population genomic data sets, one from …

Brassinosteroids (BRs) are essential plant hormones. In angiosperms, brassinolide and
castasterone, the first and second most active BRs, respectively, are synthesised by …

The treatment of complex diseases often relies on combinatorial therapy, a strategy where
drugs are used to target multiple genes simultaneously. Promising candidate genes for …

Selected mutations interfere and interact with evolutionary processes at nearby loci,
distorting allele frequency trajectories and correlations between pairs of mutations. A …

ABSTRACT RNA viruses, such as hepatitis C virus (HCV), influenza virus, and SARS-CoV-2,
are notorious for their ability to evolve rapidly under selection in novel environments. It is …

RNA structures are dynamic. As a consequence, mutational effects can be hard to
rationalize with reference to a single static native structure. We reasoned that deep …

The present review represents an update on the fundamental role played by the Rho factor,
which facilitates the process of Rho-dependent transcription termination in the prokaryotic …