Deep learning (DL) has the potential to transform medical diagnostics. However, the
diagnostic accuracy of DL is uncertain. Our aim was to evaluate the diagnostic accuracy of …

Purpose Due to the increasing demand for intensive care unit (ICU) treatment, and to
improve quality and efficiency of care, there is a need for adequate and efficient clinical …

Background High rates of overdiagnosis are a critical barrier to organized prostate cancer
screening. Magnetic resonance imaging (MRI) with targeted biopsy has shown the potential …

Background The Medical Research Council published the second edition of its framework in
2006 on developing and evaluating complex interventions. Since then, there have been …

Importance Extenuating circumstances can trigger unplanned changes to randomized trials
and introduce methodological, ethical, feasibility, and analytical challenges that can …

Patient-reported outcome measures (PROMs) are self-rated scales and indices developed
to improve the detection of the patients' subjective experience. Given that a considerable …

Importance Previous trials have suggested that vasopressin and methylprednisolone
administered during in-hospital cardiac arrest might improve outcomes. Objective To …

Randomized controlled trials and Mendelian randomization studies are two study designs
that provide randomized evidence in human biological and medical research. Both exploit …

Patient-reported outcomes (PROs) are used in clinical trials to provide valuable evidence on
the impact of disease and treatment on patients' symptoms, function and quality of life. High …

Background: Several reviews of mobile health (mHealth) physical activity (PA) interventions
suggest their beneficial effects on behavior change in adolescents and adults. Owing to the …