Proteostatic imbalance and protein spreading in amyotrophic lateral sclerosis
ME Cicardi, L Marrone, M Azzouz, D Trotti - The EMBO journal, 2021 - embopress.org
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder whose exact
causative mechanisms are still under intense investigation. Several lines of evidence …
causative mechanisms are still under intense investigation. Several lines of evidence …
Mechanisms of TDP-43 proteinopathy onset and propagation
HJ Chen, JC Mitchell - International Journal of Molecular Sciences, 2021 - mdpi.com
TDP-43 is an RNA-binding protein that has been robustly linked to the pathogenesis of a
number of neurodegenerative disorders, including amyotrophic lateral sclerosis and …
number of neurodegenerative disorders, including amyotrophic lateral sclerosis and …
Astrocyte-derived extracellular vesicles enhance the survival and electrophysiological function of human cortical neurons in vitro
Neurons derived from human induced pluripotent stem cells (hiPSCs) are powerful tools for
modeling neural pathophysiology and preclinical efficacy/toxicity screening of novel …
modeling neural pathophysiology and preclinical efficacy/toxicity screening of novel …
In a search for efficient treatment for amyotrophic lateral sclerosis: Old drugs for new approaches
MS Kukharsky, VI Skvortsova… - Medicinal Research …, 2021 - Wiley Online Library
Recent progress in understanding the pathological changes in the nervous system and in
certain other body systems (eg, immune system) that lead to the development and …
certain other body systems (eg, immune system) that lead to the development and …
Extracellular Hsp90 and protection of neuronal cells through Nrf2
Heat shock protein 90 (Hsp90), although one of the most essential intracellular chaperones,
can also play key roles in the extracellular milieu. Here, we review the properties of …
can also play key roles in the extracellular milieu. Here, we review the properties of …
Epigenetic Regulation of ALS and CMT: A Lesson from Drosophila Models
M Yamaguchi, K Omori, S Asada… - International Journal of …, 2021 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is the third most common neurodegenerative disorder
and is sometimes associated with frontotemporal dementia. Charcot–Marie–Tooth disease …
and is sometimes associated with frontotemporal dementia. Charcot–Marie–Tooth disease …
[图书][B] Evidence based validation of traditional medicines
Evidence based validation of traditional medicines Subhash C. Mandal Raja Chakraborty
Saikat Sen Editors Evidence Based Validation of Traditional Medicines A Comprehensive …
Saikat Sen Editors Evidence Based Validation of Traditional Medicines A Comprehensive …
[HTML][HTML] Applying deductive reasoning and the principles of particle physics to aging research
Aging is debatably one of the biggest mysteries for humanity, a process consisting of
myriads of genetic, molecular, environmental, and stochastic deleterious events, leading to a …
myriads of genetic, molecular, environmental, and stochastic deleterious events, leading to a …
Neurodegenerative Diseases and Small Molecule Protein Chaperone Activator of Natural Origin
Progressive neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's
disease, and amyotrophic lateral sclerosis affect millions of people around the world. In …
disease, and amyotrophic lateral sclerosis affect millions of people around the world. In …