[HTML][HTML] Epigenome-wide association studies: current knowledge, strategies and recommendations
The aetiology and pathophysiology of complex diseases are driven by the interaction
between genetic and environmental factors. The variability in risk and outcomes in these …
between genetic and environmental factors. The variability in risk and outcomes in these …
[HTML][HTML] A proteogenomic portrait of lung squamous cell carcinoma
Lung squamous cell carcinoma (LSCC) remains a leading cause of cancer death with few
therapeutic options. We characterized the proteogenomic landscape of LSCC, providing a …
therapeutic options. We characterized the proteogenomic landscape of LSCC, providing a …
[HTML][HTML] Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion
Glioblastoma multiforme (GBM) is an aggressive brain tumor for which current
immunotherapy approaches have been unsuccessful. Here, we explore the mechanisms …
immunotherapy approaches have been unsuccessful. Here, we explore the mechanisms …
[HTML][HTML] Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma
We present a proteogenomic study of 108 human papilloma virus (HPV)-negative head and
neck squamous cell carcinomas (HNSCCs). Proteomic analysis systematically catalogs …
neck squamous cell carcinomas (HNSCCs). Proteomic analysis systematically catalogs …
Radiation-related genomic profile of papillary thyroid carcinoma after the Chernobyl accident
INTRODUCTION The 1986 Chernobyl (Chornobyl in Ukrainian) nuclear power plant
accident exposed millions of individuals in the surrounding region to radioactive …
accident exposed millions of individuals in the surrounding region to radioactive …
Epigenetic reprogramming of tumor cell–intrinsic STING function sculpts antigenicity and T cell recognition of melanoma
R Falahat, A Berglund, RM Putney… - Proceedings of the …, 2021 - National Acad Sciences
Lack or loss of tumor antigenicity represents one of the key mechanisms of immune escape
and resistance to T cell–based immunotherapies. Evidence suggests that activation of …
and resistance to T cell–based immunotherapies. Evidence suggests that activation of …
[HTML][HTML] TET2 mutations are associated with hypermethylation at key regulatory enhancers in normal and malignant hematopoiesis
Mutations in the epigenetic modifier TET2 are frequent in myeloid malignancies and clonal
hematopoiesis of indeterminate potential (CHIP) and clonal cytopenia of undetermined …
hematopoiesis of indeterminate potential (CHIP) and clonal cytopenia of undetermined …
[HTML][HTML] Blood DNA methylation and COVID-19 outcomes
J Balnis, A Madrid, KJ Hogan, LA Drake, HC Chieng… - Clinical …, 2021 - Springer
Background There are no prior reports that compare differentially methylated regions of DNA
in blood samples from COVID-19 patients to samples collected before the SARS-CoV-2 …
in blood samples from COVID-19 patients to samples collected before the SARS-CoV-2 …
[HTML][HTML] Epigenetic dysregulation of immune-related pathways in cancer: bioinformatics tools and visualization
A Berglund, RM Putney, I Hamaidi, S Kim - Experimental & Molecular …, 2021 - nature.com
Cancer immune evasion is one of the hallmarks of carcinogenesis. Cancer cells employ
multiple mechanisms to avoid immune recognition and suppress antitumor immune …
multiple mechanisms to avoid immune recognition and suppress antitumor immune …
[HTML][HTML] Fifteen years of the Australian Imaging, Biomarkers and Lifestyle (AIBL) study: progress and observations from 2,359 older adults spanning the spectrum from …
C Fowler, SR Rainey-Smith, S Bird… - Journal of …, 2021 - content.iospress.com
Background: The Australian Imaging, Biomarkers and Lifestyle (AIBL) Study commenced in
2006 as a prospective study of 1,112 individuals (768 cognitively normal (CN), 133 with mild …
2006 as a prospective study of 1,112 individuals (768 cognitively normal (CN), 133 with mild …