Transcription factors (TFs) represent key biological players in diseases including cancer,
autoimmunity, diabetes and cardiovascular disease. However, outside nuclear receptors …

Eukaryotic DNA-binding proteins operate in the context of chromatin, where nucleosomes
are the elementary building blocks. Nucleosomal DNA is wrapped around a histone core …

Chromatin accessibility is a hallmark of regulatory regions, entails transcription factor (TF)
binding and requires nucleosomal reorganization. However, it remains unclear how …

The majority of gene transcripts generated by RNA polymerase II in mammalian genomes
initiate at CpG island (CGI) promoters,, yet our understanding of their regulation remains …

Transcription progression is governed by multitasking regulators including SPT5, an
evolutionarily conserved factor implicated in virtually all transcriptional steps from enhancer …

Pioneer transcription factors such as OCT4 can target silent genes embedded in
nucleosome-dense regions. How nucleosome interaction enables transcription factors to …

Transcriptional coregulators, which mediate chromatin-dependent transcriptional signaling,
represent tractable targets to modulate tumorigenic gene expression programs with small …

Transcription elongation has emerged as a regulatory hub in gene expression of
metazoans. A major control point occurs during early elongation before RNA polymerase II …

The ARID1A subunit of SWI/SNF chromatin remodeling complexes is a potent tumor
suppressor. Here, a degron is applied to detect rapid loss of chromatin accessibility at …

Fusion transcription factors generated by genomic translocations are common drivers of
several types of cancers including sarcomas and leukemias. Oncofusions of the FET (FUS …