[HTML][HTML] Single nucleotide polymorphisms (SNPs) in prostate cancer: its implications in diagnostics and therapeutics

KS Allemailem, A Almatroudi, F Alrumaihi… - American journal of …, 2021 - ncbi.nlm.nih.gov
Prostate cancer is one of the most frequently diagnosed malignancies in developed
countries and approximately 248,530 new cases of prostate cancer are likely to be …

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

H Sung, J Ferlay, RL Siegel… - CA: a cancer journal …, 2021 - Wiley Online Library
This article provides an update on the global cancer burden using the GLOBOCAN 2020
estimates of cancer incidence and mortality produced by the International Agency for …

Rising prostate cancer incidence in sub-Saharan Africa: a trend analysis of data from the African cancer registry network

TP Seraphin, WY Joko-Fru, B Kamaté… - … Biomarkers & Prevention, 2021 - AACR
Background: Prostate cancer is the leading cancer in men in sub-Saharan Africa (SSA)
regarding incidence and mortality. Published data from a few registries in SSA suggest that …

[HTML][HTML] Dietary phytochemicals in zinc homeostasis: a strategy for prostate cancer management

CK Singh, G Chhabra, A Patel, H Chang, N Ahmad - Nutrients, 2021 - mdpi.com
Studies have suggested an important role of the trace element zinc (Zn) in prostate biology
and functions. Zn has been shown to exist in very high concentrations in the healthy prostate …

[HTML][HTML] Somatic driver mutation prevalence in 1844 prostate cancers identifies ZNRF3 loss as a predictor of metastatic relapse

M Fraser, J Livingstone, JL Wrana, A Finelli… - Nature …, 2021 - nature.com
Driver gene mutations that are more prevalent in metastatic, castration-resistant prostate
cancer (mCRPC) than localized disease represent candidate prognostic biomarkers. We …

Lipophagy and prostate cancer: association with disease aggressiveness and proximity to periprostatic adipose tissue

A Fontaine, D Bellanger, R Guibon… - The Journal of …, 2021 - Wiley Online Library
The prostate gland is surrounded by periprostatic adipose tissue (PPAT), which is believed
to play a role in prostate cancer (PCa) progression. Cancer cells can take up lipids from the …

EWI‐2 controls nucleocytoplasmic shuttling of EGFR signaling molecules and miRNA sorting in exosomes to inhibit prostate cancer cell metastasis

C Fu, Q Zhang, A Wang, S Yang, Y Jiang… - Molecular …, 2021 - Wiley Online Library
Early and accurate diagnosis of prostate cancer (PCa) is extremely important, as metastatic
PCa remains hard to treat. EWI‐2, a member of the Ig protein subfamily, is known to inhibit …

Prostate-specific antigen testing and opportunistic prostate cancer screening: a cohort study in England, 1998–2017

AK Clift, CAC Coupland, J Hippisley-Cox - British Journal of General …, 2021 - bjgp.org
Background Prostate cancer is a leading cause of cancer-related death. Interpreting the
results from trials of screening with prostate-specific antigen (PSA) is complex in terms of …

[HTML][HTML] Influence of dosimetry method on bone lesion absorbed dose estimates in PSMA therapy: application to mCRPC patients receiving Lu-177-PSMA-I&T

J Brosch-Lenz, C Uribe, A Gosewisch, L Kaiser… - EJNMMI physics, 2021 - Springer
Background Patients with metastatic, castration-resistant prostate cancer (mCRPC) present
with an increased tumor burden in the skeleton. For these patients, Lutetium-177 (Lu-177) …

[HTML][HTML] Parameters predicting [18F]PSMA-1007 scan positivity and type and number of detected lesions in patients with biochemical recurrence of prostate cancer

N Ahmadi Bidakhvidi, A Laenen, S Jentjens… - EJNMMI research, 2021 - Springer
Background Detection of the site of recurrence using PSMA-PET/CT is important to guide
treatment in patients with biochemical recurrence of prostate cancer (PCa). The aim of this …