The replication-timing program constitutes a key element of the organization and
coordination of numerous nuclear processes in eukaryotes. This program is established at a …

Loading of the MCM replicative helicase at origins of replication is a highly regulated
process that precedes DNA replication in all eukaryotes. The stoichiometry of MCM loaded …

Eukaryotic DNA replication initiates during S phase from origins that have been licensed in
the preceding G1 phase. Here, we compare ChIP-seq profiles of the licensing factors Orc2 …

DNA replication initiates at genomic locations known as origins of replication, which, in S.
cerevisiae, share a common DNA consensus motif. Despite being virtually nucleosome-free …

The minichromosome maintenance (MCM) helicase physically interacts with the
recombination proteins Rad51 and Rad52 from yeast to human cells. We show, in …

Safeguards against excess DNA replication are often dysregulated in cancer, and driving
cancer cells towards over-replication is a promising therapeutic strategy. We determined …

The spatio-temporal program of genome replication across eukaryotes is thought to be
driven both by the uneven loading of pre-replication complexes (pre-RCs) across the …

Quiescent cells reside in G0 phase, which is characterized by the absence of cell growth
and proliferation. These cells remain viable and re-enter the cell cycle when prompted by …

Background:(1-(2-hydroxy-5-nitrophenyl)(4-hydroxyphenyl) methyl) indoline-4-carbonitrile
(HIC), an agonist of the P2Y1 receptor (P2Y1R), induces cell death in prostate cancer cells …

Origins of DNA replication are specified by the ordered recruitment of replication factors in a
cell-cycle–dependent manner. The assembly of the pre-replicative complex in G1 and the …