Replication stress, genomic instability, and replication timing: A complex relationship
LM Briu, C Maric, JC Cadoret - International journal of molecular sciences, 2021 - mdpi.com
The replication-timing program constitutes a key element of the organization and
coordination of numerous nuclear processes in eukaryotes. This program is established at a …
coordination of numerous nuclear processes in eukaryotes. This program is established at a …
The capacity of origins to load MCM establishes replication timing patterns
L Dukaj, N Rhind - PLoS Genetics, 2021 - journals.plos.org
Loading of the MCM replicative helicase at origins of replication is a highly regulated
process that precedes DNA replication in all eukaryotes. The stoichiometry of MCM loaded …
process that precedes DNA replication in all eukaryotes. The stoichiometry of MCM loaded …
Human ORC/MCM density is low in active genes and correlates with replication time but does not delimit initiation zones
N Kirstein, A Buschle, X Wu, S Krebs, H Blum… - Elife, 2021 - elifesciences.org
Eukaryotic DNA replication initiates during S phase from origins that have been licensed in
the preceding G1 phase. Here, we compare ChIP-seq profiles of the licensing factors Orc2 …
the preceding G1 phase. Here, we compare ChIP-seq profiles of the licensing factors Orc2 …
Methylation of histone H3 at lysine 37 by Set1 and Set2 prevents spurious DNA replication
DNA replication initiates at genomic locations known as origins of replication, which, in S.
cerevisiae, share a common DNA consensus motif. Despite being virtually nucleosome-free …
cerevisiae, share a common DNA consensus motif. Despite being virtually nucleosome-free …
Physical interactions between MCM and Rad51 facilitate replication fork lesion bypass and ssDNA gap filling by non-recombinogenic functions
MJ Cabello-Lobato, C Gonzalez-Garrido… - Cell Reports, 2021 - cell.com
The minichromosome maintenance (MCM) helicase physically interacts with the
recombination proteins Rad51 and Rad52 from yeast to human cells. We show, in …
recombination proteins Rad51 and Rad52 from yeast to human cells. We show, in …
Dynamics of replication origin over-activation
H Fu, CE Redon, BL Thakur, K Utani… - Nature …, 2021 - nature.com
Safeguards against excess DNA replication are often dysregulated in cancer, and driving
cancer cells towards over-replication is a promising therapeutic strategy. We determined …
cancer cells towards over-replication is a promising therapeutic strategy. We determined …
Chromosomal Mcm2-7 distribution and the genome replication program in species from yeast to humans
EJ Foss, S Sripathy, T Gatbonton-Schwager… - PLoS …, 2021 - journals.plos.org
The spatio-temporal program of genome replication across eukaryotes is thought to be
driven both by the uneven loading of pre-replication complexes (pre-RCs) across the …
driven both by the uneven loading of pre-replication complexes (pre-RCs) across the …
Chromatin structure restricts origin utilization when quiescent cells re-enter the cell cycle
PH Lee, MA Osley - Nucleic Acids Research, 2021 - academic.oup.com
Quiescent cells reside in G0 phase, which is characterized by the absence of cell growth
and proliferation. These cells remain viable and re-enter the cell cycle when prompted by …
and proliferation. These cells remain viable and re-enter the cell cycle when prompted by …
Functional characterization of HIC, a P2Y1 agonist, as a p53 stabilizer for prostate cancer cell death induction
HT Thu Le, A Murugesan, NR Candeias… - Future Medicinal …, 2021 - Taylor & Francis
Background:(1-(2-hydroxy-5-nitrophenyl)(4-hydroxyphenyl) methyl) indoline-4-carbonitrile
(HIC), an agonist of the P2Y1 receptor (P2Y1R), induces cell death in prostate cancer cells …
(HIC), an agonist of the P2Y1 receptor (P2Y1R), induces cell death in prostate cancer cells …
Cell-cycle–dependent chromatin dynamics at replication origins
Origins of DNA replication are specified by the ordered recruitment of replication factors in a
cell-cycle–dependent manner. The assembly of the pre-replicative complex in G1 and the …
cell-cycle–dependent manner. The assembly of the pre-replicative complex in G1 and the …