Cannabis use has been increasing in recent years, particularly among women, and one of
the most common uses of cannabis for medical purposes is pain relief. Pain conditions and …

Cannabinoids are a family of heterogeneous compounds that mostly interact with receptors
eliciting several physiological effects both in the central and peripheral nervous systems and …

Inspired by the medicinal properties of the plant Cannabis sativa and its principal
component (−)-trans-Δ9-tetrahydrocannabinol (THC), researchers have developed a variety …

Although cannabinoids have been used for centuries for diverse pathological conditions,
recently, their clinical interest and application have emerged due to their diverse …

Heterotrimeric G proteins constitute the primary transducers of G protein–coupled receptor
(GPCR) signaling. In addition to mediating ligand-induced GPCR activation, G proteins …

Cannabidiol (CBD), one of the primary non-euphoric components in the Cannabis sativa L.
plant, has undergone clinical development over the last number of years as a therapeutic for …

Cannabinoid receptor 2 (CB2) is a promising target for the treatment of neuroinflammation
and other diseases. However, a lack of understanding of its complex signaling in cells and …

The type-1 cannabinoid receptor (CB 1) is a promising drug target for a wide range of
diseases. However, many existing and novel candidate ligands for CB 1 have shown only …

Background: marijuana, the common name for cannabis sativa preparations, is one of the
most consumed drug all over the world, both at therapeutical and recreational levels. With …

The type 1 and type 2 cannabinoid receptors are G protein-coupled receptors implicated in a
variety of physiological processes and diseases. Synthetic cannabinoid receptor agonists …