Mitochondrial DNA variation and cancer
PK Kopinski, LN Singh, S Zhang, MT Lott… - Nature Reviews …, 2021 - nature.com
Variation in the mitochondrial DNA (mtDNA) sequence is common in certain tumours. Two
classes of cancer mtDNA variants can be identified: de novo mutations that act as 'inducers' …
classes of cancer mtDNA variants can be identified: de novo mutations that act as 'inducers' …
Thyroid carcinoma: phenotypic features, underlying biology and potential relevance for targeting therapy
J Hu, IJ Yuan, S Mirshahidi, A Simental, SC Lee… - International journal of …, 2021 - mdpi.com
Thyroid carcinoma consists a group of phenotypically heterogeneous cancers. Recent
advances in biological technologies have been advancing the delineation of genetic …
advances in biological technologies have been advancing the delineation of genetic …
Radiation-related genomic profile of papillary thyroid carcinoma after the Chernobyl accident
INTRODUCTION The 1986 Chernobyl (Chornobyl in Ukrainian) nuclear power plant
accident exposed millions of individuals in the surrounding region to radioactive …
accident exposed millions of individuals in the surrounding region to radioactive …
DAXX represents a new type of protein-folding enabler
Protein quality control systems are crucial for cellular function and organismal health. At
present, most known protein quality control systems are multicomponent machineries that …
present, most known protein quality control systems are multicomponent machineries that …
Respiratory complex and tissue lineage drive recurrent mutations in tumour mtDNA
Mitochondrial DNA (mtDNA) encodes protein subunits and translational machinery required
for oxidative phosphorylation (OXPHOS). Using repurposed whole-exome sequencing data …
for oxidative phosphorylation (OXPHOS). Using repurposed whole-exome sequencing data …
The genomic landscape of thyroid cancer tumourigenesis and implications for immunotherapy
A Singh, J Ham, JW Po, N Niles, T Roberts, CS Lee - Cells, 2021 - mdpi.com
Thyroid cancer is the most prevalent endocrine malignancy that comprises mostly indolent
differentiated cancers (DTCs) and less frequently aggressive poorly differentiated (PDTC) or …
differentiated cancers (DTCs) and less frequently aggressive poorly differentiated (PDTC) or …
Molecular alterations in Hürthle cell nodules and preoperative cancer risk
WR Doerfler, AV Nikitski, EM Morariu… - Endocrine-related …, 2021 - erc.bioscientifica.com
Hürthle cell carcinoma (HCC) is a distinct type of thyroid cancer genetically characterized by
DNA copy number alterations (CNA), typically of genome haploidization type (GH-type) …
DNA copy number alterations (CNA), typically of genome haploidization type (GH-type) …
Progress and challenges in thyroid cancer management
MR Haymart - Endocrine Practice, 2021 - Elsevier
The state of thyroid cancer in 2021 is reviewed including the prevalence of thyroid cancer,
vulnerable patient groups such as women and young adults, and known and hypothesized …
vulnerable patient groups such as women and young adults, and known and hypothesized …
Molecular genetics of follicular-derived thyroid cancer
E Macerola, AM Poma, P Vignali, A Basolo, C Ugolini… - Cancers, 2021 - mdpi.com
Simple Summary Thyroid tumors that derive from follicular cells are not a homogeneous
entity, showing variable morphological appearance and different degrees of differentiation …
entity, showing variable morphological appearance and different degrees of differentiation …
Genetics, diagnosis, and management of Hürthle cell thyroid neoplasms
DG McFadden, PM Sadow - Frontiers in endocrinology, 2021 - frontiersin.org
Hürthle cell lesions have been a diagnostic conundrum in pathology since they were first
recognized over a century ago. Controversy as to the name of the cell, the origin of the cell …
recognized over a century ago. Controversy as to the name of the cell, the origin of the cell …