Simple Summary Prostate cancer continues to exert a significant public health burden
across the globe with hundreds of thousands of new diagnoses per year. There have been …

Motivation The activity of a transcription factor (TF) in a sample of cells is the extent to which
it is exerting its regulatory potential. Many methods of inferring TF activity from gene …

Background Metastatic progress is the primary cause of death in most cancers, yet the
regulatory dynamics driving the cellular changes necessary for metastasis remain poorly …

Stress response pathways (SRPs) mitigate the cellular effects of chemicals, but excessive
perturbation can lead to adverse outcomes. Here, we investigated a computational …

Reconstruction of transcriptional regulatory networks (TRNs) is a powerful approach to
unravel the gene expression programs involved in healthy and disease states of a cell …

Prostate cancer is a high-incidence cancer that requires improved patient stratification to
ensure accurate predictions of risk and treatment response. Due to the significant …