Advances in microfluidic in vitro systems for neurological disease modeling

PM Holloway, S Willaime‐Morawek… - Journal of …, 2021 - Wiley Online Library
Neurological disorders are the leading cause of disability and the second largest cause of
death worldwide. Despite significant research efforts, neurology remains one of the most …

A review on microwell and microfluidic geometric array fabrication techniques and its potential applications in cellular studies

AA Manzoor, L Romita… - The Canadian Journal of …, 2021 - Wiley Online Library
The ability to trap precise quantities of cells or particles into confined areas has numerous
applications for biological purposes. In particular, single cell trapping has received …

A microfabricated multi-compartment device for neuron and Schwann cell differentiation

E De Vitis, V La Pesa, F Gervaso, A Romano… - Scientific Reports, 2021 - nature.com
Understanding the complex communication between different cell populations and their
interaction with the microenvironment in the central and peripheral nervous systems is …

Interaction of micropatterned topographical and biochemical cues to direct neurite growth from spiral ganglion neurons

K Truong, B Leigh, JT Vecchi, R Bartholomew, L Xu… - Hearing research, 2021 - Elsevier
Functional outcomes with neural prosthetic devices, such as cochlear implants, are limited in
part due to physical separation between the stimulating elements and the neurons they …

Gradients of Surface-Bound Laminin on Conducting Polymer Films for Potential Nerve Regeneration

O Dadras-Toussi, M Khorrami, S Majd… - … EMBS Conference on …, 2021 - ieeexplore.ieee.org
Functional nerve recovery after the injury is crucial in the field of neural interfaces. Although
numerous technologies have already been established to promote nerve regeneration …

Microfabricated porous SU-8 membranes as innervation interfaces for hiPSC-neurons in microfluidic devices

T Salpavaara, T Joki, A Skogberg… - Journal of Physics …, 2021 - iopscience.iop.org
In this study, we developed microfabricated porous membranes aimed at facilitating
innervation in 3D cell culture models. The aim of the paper is to introduce a fabrication …

Guided Axon Outgrowth of Neurons by Real-Time Femtosecond Laser Penetration on a 4 μm Thick Thin-Glass Sheet

D Anggraini, X Liu, K Okano, Y Tanaka, N Inagaki, M Li… - bioRxiv, 2021 - biorxiv.org
Transplantation of scaffold-embedded guided neurons has been reported to increase
neuronal regeneration following brain injury. However, precise axonal integration between …