The role of vitamin D in autoimmune diseases: could sex make the difference?

ML Dupuis, MT Pagano, M Pierdominici… - Biology of sex …, 2021 - Springer
Over the last decades, a central role for vitamin D in immune modulation has been well
established. The active form of vitamin D, ie, 1, 25-dihydroxyvitamin D, through the …

Pain in women: a perspective review on a relevant clinical issue that deserves prioritization

R Casale, F Atzeni, L Bazzichi, G Beretta, E Costantini… - Pain and therapy, 2021 - Springer
Introduction Gender equity and gender medicine are opportunities not to be missed, and this
Expert Group Opinion Paper on pain in women aims to review the treatment of pain …

Influence of age and sex on disease course and treatment in rheumatoid arthritis

J Nilsson, MLE Andersson, I Hafström… - … research and reviews, 2021 - Taylor & Francis
Objective More than 50% of patients with rheumatoid arthritis (RA) are> 65 years at
diagnosis. Age of onset and sex may influence the disease course, outcome and treatment …

Gender-related differences in disease activity and clinical features in patients with peripheral psoriatic arthritis: a multi-center study

MT Duruöz, HH Gezer, K Nas, E Kılıç, B Sargın… - Joint Bone Spine, 2021 - Elsevier
Objective This study sought to compare disease activity, clinical features, and patient-
reported outcomes concerning anxiety, depression, fatigue, function, quality of life, and …

Glucocorticoid use is associated with an increased risk of hypertension

RE Costello, BB Yimer, P Roads, M Jani… - Rheumatology, 2021 - academic.oup.com
Objectives Patients with RA are frequently treated with glucocorticoids (GCs), but evidence
is conflicting about whether GCs are associated with hypertension. The aim of this study was …

Cannabinoid-based therapy as a future for joint degeneration. Focus on the role of CB2 receptor in the arthritis progression and pain: an updated review

M Bryk, K Starowicz - Pharmacological Reports, 2021 - Springer
Over the last several decades, the percentage of patients suffering from different forms of
arthritis has increased due to the ageing population and the increasing risk of civilization …

Plasma expression of microRNA-425-5p and microRNA-451a as biomarkers of cardiovascular disease in rheumatoid arthritis patients

D Taverner, D Llop, R Rosales, R Ferré, L Masana… - Scientific Reports, 2021 - nature.com
To validate in a cohort of 214 rheumatoid arthritis patients a panel of 10 plasmatic
microRNAs, which we previously identified and that can facilitate earlier diagnosis of …

Asphodelus tenuifolius extracts arrested inflammation and arthritis through modulation of TNF-α, NF-κB, ILs, and COX-2 activities in in vivo models

M Saleem, A Iftikhar, M Asif, K Hussain, Alamgeer… - …, 2021 - Springer
Asphodelus tenuifolius is traditionally used in the management of rheumatic pain and
inflamed body parts. The current study validated its traditional use as an anti-arthritic and …

Predictors of unacceptable pain with and without low inflammation over 5 years in early rheumatoid arthritis—an inception cohort study

A Eberhard, S Bergman, T Mandl, T Olofsson… - Arthritis research & …, 2021 - Springer
Objectives Pain is a major symptom in patients with rheumatoid arthritis (RA). In early RA,
pain is usually due to synovitis, but can also persist despite effective anti-inflammatory …

Increased expression of extracellular vesicles is associated with the procoagulant state in patients with established rheumatoid arthritis

A Stojanovic, M Veselinovic, Y Zong… - Frontiers in …, 2021 - frontiersin.org
This study sought to identify different subpopulations of extracellular vesicles (EVs) in
plasma from female patients with established rheumatoid arthritis (RA) in relation to the …