Until recently, the nucleic acid content of platelets was considered to be fully determined by
their progenitor megakaryocyte. However, it is now well understood that additional …

The growing insights in the complex interactions between metastatic cancer-cells and
platelets have revealed that platelet tumor cell interactions in the blood stream are an …

Cancer tissues are not just simple masses of malignant cells, but rather complex and
heterogeneous collections of cellular and even non-cellular components, such as …

Although platelets are critically involved in thrombosis and hemostasis, experimental and
clinical evidence indicate that platelets promote tumor progression and metastasis through a …

It is well known that various inflammatory cells infiltrate cancer cells. Next to TAMs (tumor-
associated macrophages), TAFs (tumor-associated fibroblasts) and TANs (tumor-associated …

Platelet function can be modified by cancer cells to support tumor growth, causing
alterations in the delicate hemostatic equilibrium. Cancer-cell and platelet interactions are …

Platelets, with hemostasis and thrombosis activities, are one of the key components in the
blood circulation. As a guard, they rapidly respond to any abnormal blood vessel injury …

Purinergic receptors for extracellular nucleotides and nucleosides contribute to a vast array
of cellular and tissue functions, including cell proliferation, intracellular and transmembrane …

Introduction The association between thrombosis, cancer and inflammation is well-
established. Platelets play a major role in atherosclerosis, inflammation and immune …

Gliomas are the most common malignant brain tumors in adults, characterized by a high
proliferation and invasion. The tumor microenvironment is rich in growth-promoting signals …