Understanding tumor immune microenvironments is critical for identifying immune modifiers
of cancer progression and developing cancer immunotherapies. Recent applications of …

Drug development is a long process whose main content includes drug synthesis, drug
delivery, and drug evaluation. Compared with conventional drug development procedures …

Tumor-infiltrating myeloid cells (TIMs) are key regulators in tumor progression, but the
similarity and distinction of their fundamental properties across different tumors remain …

Abstract Purpose: Cancer-associated fibroblasts (CAFs) are an important component of the
tumor microenvironment, but a systematic investigation of their molecular characteristics and …

Objective Tumour heterogeneity represents a major obstacle to accurate diagnosis and
treatment in gastric adenocarcinoma (GA). Here, we report a systematic transcriptional atlas …

Over the past decade, genomic analyses of single cells—the fundamental units of life—have
become possible. Single-cell DNA sequencing has shed light on biological questions that …

Multi-omics allows the systematic understanding of the information flow across different
omics layers, while single omics can mainly reflect one aspect of the biological system. The …

Spinal ependymomas are the most common spinal cord tumors in adults, but their
intratumoral cellular heterogeneity has been less studied, and how spinal microglia are …

Over the past decade, there have been remarkable advances in understanding the signaling
pathways involved in cancer development. It is well-established that cancer is caused by the …

Immune infiltrates in the tumor microenvironment (TME) of breast cancer (BRCA) have been
shown to play a critical role in tumorigenesis, progression, invasion, and therapy resistance …