Effects of statins on the biological features of mesenchymal stem cells and therapeutic implications

AM Gorabi, N Kiaie, M Pirro, V Bianconi… - Heart Failure …, 2021 - Springer
Statins are well-known lipid-lowering drugs. The pleiotropic effects of statins have brought
about some beneficial effects on improving the therapeutic outcomes of cell therapy and …

Stem cell-derived exosomes: Role in the pathogenesis and treatment of atherosclerosis

H Ling, Z Guo, L Tan, Q Cao, C Song - The International Journal of …, 2021 - Elsevier
Atherosclerosis (AS) is a chronic inflammatory vascular disease characterized by the
accumulation of lipids and inflammatory debris in large arteries, high morbidity, and AS …

Metformin impairs homing ability and efficacy of mesenchymal stem cells for cardiac repair in streptozotocin-induced diabetic cardiomyopathy in rats

HI Ammar, AM Shamseldeen… - American Journal …, 2021 - journals.physiology.org
Bone marrow-derived mesenchymal stem cells (BM-MSCs) have demonstrated potential in
treating diabetic cardiomyopathy. However, patients with diabetes are on multiple drugs and …

Simvastatin accelerates the healing process of burn wound in Wistar rats through Akt/mTOR signaling pathway

P Ramhormozi, JM Ansari, S Simorgh… - Annals of Anatomy …, 2021 - Elsevier
Statins, apart from cholesterol-lowering properties, have wound healing effects. Hereby, we
aimed to assess the impact of Simvastatin (SMV), one of the most commonly used statins, on …

Combination of mesenchymal stem cells and nicorandil: an emerging therapeutic challenge against COVID-19 infection-induced multiple organ dysfunction

A Safari, V Lionetti, I Razeghian-Jahromi - Stem Cell Research & Therapy, 2021 - Springer
Abstract The recent COronaVIrus Disease (COVID)-19 pandemic has placed an
unprecedented burden on the drug development opportunity to prevent the onset of multi …