Advancing stroke recovery through improved articulation of nonpharmacological intervention dose

KS Hayward, L Churilov, EJ Dalton, A Brodtmann… - Stroke, 2021 - Am Heart Assoc
Dose articulation is a universal issue of intervention development and testing. In stroke
recovery, dose of a nonpharmaceutical intervention appears to influence outcome but is …

[HTML][HTML] Progress and challenges in preclinical stroke recovery research

VL Wolf, A Ergul - Brain Circulation, 2021 - journals.lww.com
Significant innovations in the management of acute ischemic stroke have led to an
increased incidence in the long-term complications of stroke. Therefore, there is an urgent …

[HTML][HTML] A feasibility study of expanded home-based telerehabilitation after stroke

SC Cramer, L Dodakian, V Le, A McKenzie… - Frontiers in …, 2021 - frontiersin.org
Introduction: High doses of activity-based rehabilitation therapy improve outcomes after
stroke, but many patients do not receive this for various reasons such as poor access …

[HTML][HTML] Enriched environment boosts the post-stroke recovery of neurological function by promoting autophagy

YH Deng, LL Dong, YJ Zhang, XM Zhao… - Neural Regeneration …, 2021 - journals.lww.com
Autophagy is crucial for maintaining cellular homeostasis, and can be activated after
ischemic stroke. It also participates in nerve injury and repair. The purpose of this study was …

Enhanced spontaneous motor recovery after stroke in mice treated with cerebrolysin

SR DeBoer, R Hubbard, M Mersha… - … and neural repair, 2021 - journals.sagepub.com
Background Motor recovery after stroke in humans and in rodent models is time sensitive.
Recovery in patients is a result of biological spontaneous recovery via endogenous repair …

Self-directed exergaming for stroke upper limb impairment increases exercise dose compared to standard care

M Broderick, L Almedom, E Burdet… - … and Neural Repair, 2021 - journals.sagepub.com
Background. One of the strongest modifiable determinants of rehabilitation outcome is
exercise dose. Technologies enabling self-directed exercise offer a pragmatic means to …

[HTML][HTML] Differential effects of the cell cycle inhibitor, olomoucine, on functional recovery and on responses of peri-infarct microglia and astrocytes following …

WP Yew, ND Djukic, JSP Jayaseelan… - Journal of …, 2021 - Springer
Background Following stroke, changes in neuronal connectivity in tissue surrounding the
infarct play an important role in both spontaneous recovery of neurological function and in …

Principles of neural repair and their application to stroke recovery trials

DJ Lin, SC Cramer - Seminars in neurology, 2021 - thieme-connect.com
Neural repair is the underlying therapeutic strategy for many treatments currently under
investigation to improve recovery after stroke. Repair-based therapies are distinct from acute …

Preclinical neurorehabilitation with environmental enrichment confers cognitive and histological benefits in a model of pediatric asphyxial cardiac arrest

MD Manole, MJA Hook, MA Nicholas, BP Nelson… - Experimental …, 2021 - Elsevier
Pediatric asphyxial cardiac arrest (ACA) often leaves children with physical, cognitive, and
emotional disabilities that affect overall quality of life, yet rehabilitation is neither routinely …

富集环境增强自噬促进缺血性卒中后神经功能的恢复

YH Deng, LL Dong, YJ Zhang, XM Zhao… - 中国神经再生研究(英文 …, 2021 - sjzsyj.com.cn
自噬对于维持细胞稳态至关重要, 其可在缺血性脑卒中后被激活, 参与神经损伤及恢复.
因而文章涉及观察了富集环境是否可通过影响自噬发挥神经保护作用.(1) …