Skin wound healing assisted by angiogenic targeted tissue engineering: A comprehensive review of bioengineered approaches

S Nour, R Imani, GR Chaudhry… - Journal of Biomedical …, 2021 - Wiley Online Library
Skin injuries and in particular, chronic wounds, are one of the major prevalent medical
problems, worldwide. Due to the pivotal role of angiogenesis in tissue regeneration …

[HTML][HTML] Development and application of endothelial cells derived from pluripotent stem cells in microphysiological systems models

CC Kennedy, EE Brown, NO Abutaleb… - Frontiers in …, 2021 - frontiersin.org
The vascular endothelium is present in all organs and blood vessels, facilitates the
exchange of nutrients and waste throughout different organ systems in the body, and sets …

Recent advances in the induced pluripotent stem cell‐based skin regeneration

S Choudhury, N Surendran… - Wound Repair and …, 2021 - Wiley Online Library
Skin regeneration has been a challenging clinical problem especially in cases of chronic
wounds such as diabetic foot ulcers, and epidermolysis bullosa‐related skin blisters …

Silk Fibroin Scaffold Architecture Regulates Inflammatory Responses and Engraftment of Bone Marrow‐Mononuclear Cells

N Yang, MJ Moore, PL Michael… - Advanced …, 2021 - Wiley Online Library
Despite being one of the most clinically trialed cell therapies, bone marrow‐mononuclear
cell (BM‐MNC) infusion has largely failed to fulfill its clinical promise. Implanting biomimetic …

[HTML][HTML] Patient endothelial colony-forming cells to model coronary artery disease susceptibility and unravel the role of dysregulated mitochondrial redox signalling

M Besnier, M Finemore, C Yu, KA Kott, ST Vernon… - Antioxidants, 2021 - mdpi.com
Mechanisms involved in the individual susceptibility to atherosclerotic coronary artery
disease (CAD) beyond traditional risk factors are poorly understood. Here, we describe the …

[HTML][HTML] TGF-β/Smad 信号通路在肝纤维化中的研究进展

韩道宁, 苏秀兰 - 生物医学转化, 2021 - swyxzh.ijournals.cn
摘要转化生长因子β (Transforming Growth Factor-β, TGF-β) 信号通路在调节细胞进程中起着至
关重要的作用. 就肝脏而言, TGF-β 信号通路贯穿肝脏疾病始终, 即从最初的肝细胞损伤到炎症 …

VE-cadherin-based matrix promoting the self-reconstruction of pro-vascularization microenvironments and endothelial differentiation of human mesenchymal stem …

J Xie, X Li, Y Zhang, T Tang, G Chen, H Mao… - Journal of Materials …, 2021 - pubs.rsc.org
Regulating the secretion and endothelial differentiation of human mesenchymal stem cells
(hMSCs) plays an important role in the vascularization in tissue engineering and …

Therapeutic biomaterial approaches to alleviate chronic limb threatening ischemia

G Marsico, S Martin‐Saldaña, A Pandit - Advanced Science, 2021 - Wiley Online Library
Chronic limb threatening ischemia (CLTI) is a severe condition defined by the blockage of
arteries in the lower extremities that leads to the degeneration of blood vessels and is …

Experimental study of fat derived pellets promoting wound healing in rats

L Zeng, S Zhou, C Chen, LH Zhou, X Shi, Z Wu… - …, 2021 - Taylor & Francis
To observe the effect of fat-derived pellets (FDP) on wound healing in rats, the inguinal fat of
rats was obtained, and the FDP were obtained after centrifugation. The cell activity and …

[HTML][HTML] Induced endothelial cells from peripheral arterial disease patients and neonatal fibroblasts have comparable angiogenic properties

JD Hywood, S Sadeghipour, ZE Clayton, J Yuan… - Plos one, 2021 - journals.plos.org
Induced endothelial cells (iECs) generated from neonatal fibroblasts via transdifferentiation
have been shown to have pro-angiogenic properties and are a potential therapy for …